Publications by authors named "Manuel E Lagos-Munoz"
Evaluation of the membrane permeability (PAMPA and skin) of benzimidazoles with potential cannabinoid activity and their relation with the Biopharmaceutics Classification System (BCS).
M Javiera Alvarez-Figueroa C David Pessoa-Mahana M Elisa Palavecino-González Jaime Mella-Raipán Cristián Espinosa-Bustos
AAPS PharmSciTech
June 2011
Article Synopsis
- The study assessed the permeability of five benzimidazole derivatives with potential cannabinoid effects using two membrane models: PAMPA and skin.
- Findings indicated that while PAMPA can effectively predict the intestinal absorption of these molecules as highly permeable when their Log P(oct) is below 3.0, the transdermal permeability relies heavily on the solubility of the molecules.
- Thus, PAMPA is useful for classifying permeability independent of solubility, while skin models only apply to highly soluble compounds categorized under specific Biopharmaceutics Classification System classes.