Publications by authors named "Manuel Cerini"

Introduction: Transvenous lead extraction (TLE) is generally considered a safe procedure, albeit not without risks. While gender-based disparities have been noted in short-term outcomes following TLE, a notable gap exists in understanding the long-term consequences of this procedure. The objective of this analysis was to investigate sex differences in both acute and long-term outcomes among patients who underwent TLE at a tertiary referral center.

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  • - The study analyzed outcomes of leadless pacemakers (LPMs) in patients with varying stages of chronic kidney disease (CKD) collected from the international i-LEAPER registry, focusing on major complications and electrical performance post-implantation.
  • - Results indicated that while patients with CKD experienced similar rates of major complications during and after LPM implantation compared to those with normal kidney function, all-cause mortality was notably higher in severe CKD stages (G4/G5).
  • - Additionally, patients with CKD displayed a slightly increased pacing threshold during the initial follow-up month, but overall, LPM electrical performance remained comparable across all groups. The research suggests that patients with advanced CKD are less frequently represented in LPM procedures despite
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  • This study investigated patients with Brugada syndrome (BrS) who received implantable loop recorders (ILR) to monitor their heart rhythms.
  • Out of 147 patients, 29% received ILRs, while some got implantable cardioverter-defibrillators (ICD) or continued regular follow-up.
  • Results showed that ILR patients had more episodes of suspected arrhythmic syncope and gene mutations and were generally younger; continuous monitoring helped diagnose rhythm issues without any reported adverse effects.
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  • * The review aims to explore how fibrosis contributes to genetically determined AF to enhance understanding of its underlying mechanisms and inform treatment strategies, even for non-genetic forms of the condition.
  • * Researchers will examine both genetic and epigenetic factors leading to AF and how they relate to atrial fibrosis, while drawing comparisons to non-genetic AF and discussing potential therapeutic approaches.
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  • The ESC Guidelines advise against implanting an ICD (Implantable Cardioverter-Defibrillator) within 40 days post-heart attack (MI) due to outdated evidence with limitations.
  • Despite this recommendation, many patients are still at high risk for deadly heart rhythms shortly after an acute coronary syndrome (ACS) event.
  • In these high-risk patients, early ICD implantation or using a LifeVest can potentially improve survival rates.
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Background: A complex transvenous lead extraction (TLE) procedure could be associated with lower success and higher complication rates in inexperienced hands. In this study, we aim to assess the factors that determine procedural difficulty in TLE.

Methods: We retrospectively studied 200 consecutive patients undergoing TLE in a single referral centre from June 2020 to December 2021.

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  • Transvenous lead extraction (TLE) is generally safe and effective for patients with cardiac devices, but long-term outcomes have not been extensively studied.
  • This study analyzed 191 patients who underwent TLE from 2014 to 2016, focusing on long-term survival and factors influencing outcomes, particularly differentiating between infections and non-infection reasons for the procedure.
  • Results revealed that patients with infections had significantly worse event-free survival rates and higher mortality compared to those with non-infection cases, with specific indicators like vegetation and positive blood cultures linked to poorer prognoses.
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Background: Limited data on the real-world safety and efficacy of leadless pacemakers (LPMs) post-transvenous lead extraction (TLE) are available.

Objective: The purpose of this study was to assess the long-term safety and effectiveness of LPMs following TLE in comparison with LPMs de novo implantation.

Methods: Consecutive patients who underwent LPM implantation in 12 European centers joining the International LEAdless PacemakEr Registry were enrolled.

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Introduction: The prevalence and impact of pulmonary embolism (PE) in patients with lead-related infective endocarditis undergoing transvenous lead extraction (TLE) are unknown.

Methods: Twenty-five consecutive patients with vegetations ≥10 mm at transoesophageal echocardiography were prospectively studied. Contrast-enhanced chest computed tomography (CT) was performed before (pre-TLE) and after (post-TLE) the lead extraction procedure.

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Background: Transvenous lead extraction is the standard therapy for cardiac device-related infection. In some patients, however, a hybrid surgical and transvenous approach may be necessary.

Methods And Results: We present three cases who underwent transvenous lead extraction for an infected CRT-D system.

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Superior vena cava (SVC) syndrome is a rare disease induced by thrombosis and consequent occlusion of SVC, negatively affecting morbidity and mortality. The incidence of SVC syndrome from central venous catheters and pacemaker or defibrillator leads is increasing. Optimal treatment of pacemaker or defibrillator-related SVC syndrome is not well defined.

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Introduction: We hypothesized that an accurate assessment of preoperative venography could be useful in predicting transvenous lead extraction (TLE) difficulty.

Methods And Results: A dedicated preoperative venogram was performed in consecutive patients with cardiac implantable electronic device who underwent TLE. The level of stenosis was classified as without significant stenosis, moderate, severe, and occlusion.

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  • High pacing threshold (HPT) and very high pacing threshold (VHPT) negatively affect leadless pacemaker battery life, prompting device repositioning. This study aimed to determine if intraoperative electrical parameters during Micra™ VR implants could predict device performance during follow-up.
  • The study analyzed 93 patients who underwent Micra™ VR implant, recording key metrics (R-wave sensing amplitude, pacing threshold, and impedance) during the procedure and follow-up visits at 1 and 12 months. Results showed a significant increase in R-wave sensing amplitude and a reduction in pacing threshold over time.
  • An increase of 1.5 mV in R-wave sensing after 14 minutes post-implant was a strong
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Purpose: Predictors of difficulty and complications of transvenous lead extraction (TLE) have been investigated in several studies; however, little is known about the venous anatomical characteristics that can have an impact on procedural outcomes. Among them, the persistent left superior vena cava (PLSVC) is a common anomaly often discovered incidentally during cardiac device implantation and could raise concerns if TLE is indicated. We report technical considerations and outcomes of TLE for two patients with leads implanted via PLSVC.

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We report the case of a patient implanted with an implantable defibrillator endowed with a multisensor algorithm for heart failure monitoring. Automatic measurement of multiple clinical variables allowed to detect impending heart failure decompensation and showed its ability to facilitate differential diagnosis in the context of the current COVID-19 pandemic.

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Theleadless pacemaker (LLPM) therapy has been developed in recent years to overcome the transvenous lead and device pocket-related complications. The LLPMs now available are self-contained right ventricular pacemakers and are limited to single-chamber ventricular pacing modality. This literature review deals with the current status of LLPM technology and current areas of clinical applicability.

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Purpose: The persistent left superior vena cava (PLSVC) is usually asymptomatic and creates a challenge when detected incidentally during cardiac resynchronization therapy defibrillator (CRT-D) implantation. The purpose of our cases is to show different anatomical variables of PLSVC and different strategies used for CRT-D implantation.

Methods: Four cases of PLSVC were presented.

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Importance: Virus infection has been widely described as one of the most common causes of myocarditis. However, less is known about the cardiac involvement as a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Objective: To describe the presentation of acute myocardial inflammation in a patient with coronavirus disease 2019 (COVID-19) who recovered from the influenzalike syndrome and developed fatigue and signs and symptoms of heart failure a week after upper respiratory tract symptoms.

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Aims: A validated risk stratification schema for transvenous lead extraction (TLE) could improve the management of these procedures. We aimed to derive and validate a scoring system to efficiently predict the need for advanced tools to achieve TLE success.

Methods And Results: Between November 2013 and March 2018, 1960 leads were extracted in 973 consecutive TLE procedures in two national referral sites using a stepwise approach.

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  • The first successful human retrieval of a Micra transcatheter pacing system (TPS) was reported, which is significant for cardiac patients.
  • A 41-year-old woman with third-degree atrioventricular block had the device implanted in her right ventricle for 29 months before it showed low battery issues.
  • During the retrieval process, a new leadless pacemaker was also successfully implanted, ensuring the patient continued to receive optimal pacing.
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We describe a management strategy of a leadless pacemaker recall (LP) via extraction in a pacemaker-dependent patient with a history of multiple previous device implants. We performed a two-step procedure. First, we implanted a second LP in the right ventricle.

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A 72-year-old man with a dual-chamber implantable defibrillator was referred to our center for transvenous lead extraction because of pocket infection and presence of an abandoned lead. We decided to proceed with a video-assisted thoracoscopic approach because of patient history and documented complete occlusion of the right subclavian vein. During the use of excimer laser for persistent adhesions, the ventricular lead broke down at the level of cavoatrial junction.

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