Robot-assisted vaginal hysterectomy: two cases.

Hysterectomy remains the most frequent surgical gynaecological procedure. We report two cases of robot-assisted vaginal hysterectomy and show its feasibility. Robotic assistance in vaginal hysterectomy could combine both the advantage of the vaginal route (reducing surgical length, blood loss, hospitalisation and recovery), and the advantage of the robot assistance (3D endoscopic vision, easier instrumental handling, surgical ergonomics) especially when the hysterectomy is difficult.

Photodiagnosis and photodynamic therapy of peritoneal metastasis of ovarian cancer.

Ovarian cancer is among the deadliest in women. Current treatment strategies fail to cure many patients owing to the difficulties of eradicating peritoneal implants frequently associated with this pathology. Photodynamic therapy represents a promising treatment as it offers many advantages over alternative strategies: diagnostic properties, specific targeting of abnormal cells, possibility to be combined with other therapies.

Continuous or fractionated photodynamic therapy? Comparison of three PDT schemes for ovarian peritoneal micrometastasis treatment in a rat model.

Objective: This experimental study aimed to compare three illumination schemes to optimize hexaminolaevulinate (HAL)-PDT in a rat tumor model with advanced ovarian cancer.

Materials And Methods: Peritoneal carcinomatosis was induced by intraperitoneal 5×10(6)NuTu-19 cells injection in 60 female rats Fisher 344. Carcinomatosis was obtained 50 days post-tumor induction.

Comparison of continuous and fractionated illumination during hexaminolaevulinate-photodynamic therapy.

Objective: This experimental study aimed to compare continuous and fractionated illumination to optimize hexaminolaevulinate (HAL)-photodynamic therapy (PDT) in a rat tumour model with advanced ovarian cancer.

Materials And Methods: Intraperitoneal 10(6) Nu Tu-19 cells were injected in 36 female rats Fisher 344. Peritoneal carcinomatosis was obtained 26 days post-tumour induction.

Protoporphyrin IX fluorescence photobleaching is a useful tool to predict the response of rat ovarian cancer following hexaminolevulinate photodynamic therapy.

Objective: Accurate dosimetry was shown to be critical to achieve effective photodynamic therapy (PDT). This study aimed to assess the reliability of in vivo protoporphyrin IX (PpIX) fluorescence photobleaching as a predictive tool of the hexaminolevulinate PDT (HAL-PDT) response in a rat model of advanced ovarian cancer.

Materials And Methods: Intraperitoneal 10(6) NuTu 19 cells were injected in 26 female rats Fisher 344.

Evaluation of ALA-PDT of ovarian cancer in the Fisher 344 rat tumor model.

Objective: This study aimed to evaluate aminolevulinic acid-photodynamic therapy (ALA-PDT) in an experimental tumor model to expand the use of PDT in the treatment of ovarian cancer with peritoneal carcinosis.

Materials And Methods: 5-Aminolevulinic acid (ALA) (Photocure ASA, Norway) 60mg/kg was injected in the peritoneum cavity of 45 female rats Fisher with induced peritoneal metastases of ovarian cancer. ALA-PDT was performed 4h later with two different lasers: (1) laser diode (Diomed, Cambridge, UK), at 630nm, 100mW/cm(2), or (2) KTP laser (Laser Quantum, Stockport, UK), 532nm, 30mW/cm(2).