Publications by authors named "Manuel Ap Vilela"
Article Synopsis
- - Best Vitelliform Macular Dystrophy (BVMD) is a hereditary retinal disease linked to dominant gene variants, and while initial classifications relied on traditional imaging techniques, advancements in retinal imaging have provided new insights into its pathology.
- - Studies using quantitative fundus autofluorescence suggest that the accumulation of lipofuscin (a key feature of BVMD) may be caused by a lack of alignment between photoreceptors and retinal pigment epithelium over time, rather than being a direct result of the genetic defect.
- - Modern imaging methods like Optical Coherence Tomography (OCT) and OCT Angiography have revealed progression patterns in BVMD, highlighting the importance of these tools for accurate diagnosis,
Retinal vessel tortuosity has been used in the diagnosis and management of different clinical situations. Notwithstanding, basic concepts, standards and tools of measurement, reliable normative data and clinical applications have many gaps or points of divergence. In this review we discuss triggering causes of retinal vessel tortuosity and resources used to assess and quantify it, as well as current limitations.
View Article and Find Full Text PDFRetinal vein occlusion (RVO) is one of the most prevalent causes of visual loss in the Western World. Its pathogenesis is still not completely known. Chronic macular edema and ischemia compromise the functional and anatomical status of the retina.
View Article and Find Full Text PDFBackground: Smartphone fundoscopy is a new option for visualizing the ocular fundus but must be validated before being included in population-based examinations. Our aim was to evaluate the quality of fundoscopic images obtained via smartphone and to compare their agreement with retinal camera images or clinical examination.
Methods: The database for this study included all observational studies with smartphone fundoscopy that have comparative analyses with the gold standard methods.
Objective: To describe, in a multimodal way, a new RHO gene mutation with lysine-for-asparagine substitution in autosomal dominant retinitis pigmentosa.
Methods: Case report. Retrospective data analysis.
Background: The ocular effects of obesity and hypertension need to be established and can be used as prognostic markers.
Objective: To estimate the prevalence of ophthalmological alterations in children and adolescents who are overweight and/or have SAH.
Methods: The database for this study included all observational studies (CS, cohort, case-control and "baseline" description of randomized clinical trials) with children and/or adolescents who were overweight, obese or had SAH and that measured ophthalmological alterations.
Objective: To assess asthenopia prevalence and associated factors in schoolchildren aged 6-16.
Methods: This was a cross-sectional study of all children attending the first to eighth grades at two public schools in the urban region of a medium-sized town in Southern Brazil between April and December 2012. A questionnaire on socioeconomic and cultural matters was answered by parents, while the children answered a questionnaire on asthenopia-related symptoms.