From Propargylic Alcohols to Substituted Thiochromenes: -Disubstituent Effect in Intramolecular Alkyne Iodo/hydroarylation.

This work describes the 6-- cyclization of -aryl propargyl sulfides to afford 2-thiochromenes. The substitution at the propargylic position plays a crucial role in allowing intramolecular silver-catalyzed alkyne hydroarylation and -iodosuccinimide-promoted iodoarylation. Additionally, a PTSA-catalyzed thiolation reaction of propargylic alcohols was developed to synthesize the required tertiary -aryl propargyl ethers.

Multi-component reactions involving group 6 Fischer carbene complexes: a source of inspiration for future catalytic transformations.

The ability of heteroatom stabilized Fischer carbene complexes (FCCs) to participate in multicomponent reactions (MCRs) has become a characteristic of such organometallics, particularly of chromium carbenes. This feature article updates the main results in this field during the last lustrum, highlighting the ability of FCCs for the construction of densely functionalized frameworks, mainly through the successive incorporation of unsaturated moieties (alkynes, CO ligands,…) in a sequential manner. Examples where up to seven components are coupled will be presented.

Gold-catalyzed intermolecular hetero-dehydro-diels-alder cycloaddition of captodative dienynes with nitriles: a new reaction and regioselective direct access to pyridines.

For the first time, nitriles are used as 2pi electron component in a gold-catalyzed intermolecular hetero-dehydro-Diels-Alder cycloaddition with captodative enynes leading to the regioselective formation of pyridines.

A novel [2 + 2 + 1]/[2 + 1] tandem cycloaddition reaction of Fischer alkynyl carbenes with strained bicyclic olefins.

The reaction of strained bicyclic olefins with alkynyl carbenes and terminal olefins involves the creation of five new sigma C-C bonds with the concomitant formation of two new rings, thus creating a complex and densely functionalized structure in a single operation.