PEGylated β-cyclodextrins: Click synthesis and in vitro biological insights.

We present three easily rationalized star-shaped PEGylated β-cyclodextrin (βCD) derivatives synthesized via conjugation of different molecular weight PEG chains (5000, 2000, and 550 Da) to the βCD primary face by click chemistry (βCD-PEG, βCD-PEG, βCD-PEG respectively). βCDPEG systems are envisioned to further carry bioactive molecules, therefore, their interactions with biological interfaces must be determined at an early stage of development. Hence, the effect of βCDPEGs chain length on cell viability was investigated.