Publications by authors named "Manuel A Aparicio-Cuevas"
During our ongoing research on fungal strains from unexplored sources, the reinvestigation of the CHCl-MeOH extract of the marine-facultative sp. MEXU 27854 yielded a new -methyl cyclic pentapeptide () along with known butyrolactone II and PF1233 A. In addition, from the marine-facultative MEXU 29901, a new alternariol glucoside, 10-[-D-(4-methoxyl-glucopyranosyl)]-4--methylalternariol () and known alternariol 4-methyl ether, alternariol and beauvericin, were isolated.
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- Two new compounds, dioxomorpholines 1 and 2, along with three derivatives (3-5) and the known compound PF1233 B (6), were extracted from a marine Aspergillus species.
- The structural identification of these compounds was achieved using advanced NMR and HRESIMS techniques, with the absolute configuration of 1 and 2 determined through vibrational circular dichroism spectra analysis.
- While compounds 3, 5, and 6 showed no toxicity to various human cancer cell lines, they were effective in inhibiting P-glycoprotein, which helps counteract multidrug resistance, particularly in doxorubicin-resistant cells.
Recycling liquid chromatography was used for the isolation and purification of resin glycosides from the CHCl3-soluble extracts prepared using flowers of Ipomoea wolcottiana Rose var. wolcottiana. Bioassay-guided fractionation, using modulation of both antibiotic activity against multidrug-resistant strains of Gram-negative bacteria and vinblastine susceptibility in breast carcinoma cells, was used to isolate the active glycolipids as modulators of the multidrug resistance phenotype.
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