Publications by authors named "Manthos G Giannoulis"
Article Synopsis
- Improving physical function and mobility in the aging population is a key medical priority, as factors like muscle mass and strength decline with age, leading to frailty and disability among older men.
- Hormones such as growth hormone (GH), insulin-like growth factor 1 (IGF-I), and testosterone (T) play crucial roles in muscle adaptation to exercise, but their levels decrease with age, contributing to diminished physical function.
- While testosterone has shown effectiveness in improving muscle mass and strength in older men, growth hormone alone has not, and there is potential benefit in combining both hormones; however, more research is needed to ensure the long-term safety and effectiveness of this combined hormone replacement therapy.
Context: Alterations of protein turnover may contribute to the progressive decline of muscle mass with aging.
Objective: Our objective was to examine the effects of near-physiological recombinant human GH and/or testosterone (T) administration to older men on whole body protein kinetics and muscle gene expression.
Design, Settings, And Participants: A 6-month randomized, double-blind, placebo-controlled trial in 21 healthy elderly men aged 65-75 yr, was performed.
Objective: To assess the effects of low dose recombinant growth hormone (GH), testosterone (T) and combined GH and T, on lipid profiles and very low density lipoprotein apolipoprotein B (VLDL apoB) metabolism.
Design And Patients: Sixty-nine healthy elderly men (65-80 yr) were studied in a six month double-blind, placebo-controlled trial. Participants were randomised to placebo GH and placebo T (P), GH and placebo T (GH), T and placebo GH (T) or GH and T (GHT).
Context: Declines in GH and testosterone (Te) secretion may contribute to the detrimental aging changes of elderly men.
Objective: To assess the effects of near-physiological GH with/without Te administration on lean body mass, total body fat, midthigh muscle cross-section area, muscle strength, aerobic capacity, condition-specific quality of life (Age-Related Hormone Deficiency-Dependent Quality of Life questionnaire), and generic health status (36-Item Short-Form Health Survey) of older men.
Design, Settings, And Participants: A 6-month, randomized, double-blind, placebo-controlled trial was performed on 80 healthy, community-dwelling, older men (age, 65-80 yr).