Contractions Induced in Human Pulmonary Arteries by a HS Donor, GYY 4137, Are Inhibited by Low-Frequency (20 kHz) Ultrasound.

The present study aimed to investigate the effect of a HS donor, GYY 4137, on human pulmonary arteries and whether low-frequency ultrasound (20 kHz, 4 W/cm) inhibits GYY 4137 contractions. Functional studies were conducted on human and rat pulmonary arteries mounted on microvascular myographs. We placed an ultrasonic gadget in the tissue organ bath to insonate the arteries with low-frequency ultrasound.

Low-frequency ultrasound for pulmonary hypertension therapy.

Background: Currently, there are no reliable clinical tools that allow non-invasive therapeutic support for patients with pulmonary arterial hypertension. This study aims to propose a low-frequency ultrasound device for pulmonary hypertension therapy and to demonstrate its potential.

Methods: A novel low-frequency ultrasound transducer has been developed.

Development of a Low-Frequency Piezoelectric Ultrasonic Transducer for Biological Tissue Sonication.

The safety of ultrasound exposure is very important for a patient's well-being. High-frequency (1-10 MHz) ultrasound waves are highly absorbed by biological tissue and have limited therapeutic effects on internal organs. This article presents the results of the development and application of a low-frequency (20-100 kHz) ultrasonic transducer for sonication of biological tissues.

Stock price reaction to the drug development setbacks in the pharmaceutical industry.

Background: Investments in pharmaceutical companies remain challenging due to the inherent uncertainties of risk assessment.

Objectives: Our paper aims to assess the impact of the drug development setbacks (DDS) on the stock price of pharmaceutical companies while taking into account the company's financial situation, pipeline size and trend of the stock price before the DDS.

Methods: The model-based clustering based on finite Gaussian mixture modeling was employed to identify the clusters of pharmaceutical companies with homogenous parameters.

Local Vibrational Therapy for Essential Tremor Reduction: A Clinical Study.

tremor is an unintentional and rhythmic movement of any part of the body that is a typical symptom of Essential Tremor (ET). ET impairs the quality of life of patients and is treated with pharmacotherapy. We investigated the tremor reduction efficacy of an innovative vibrational medical device (IMD) in ET patients.

Low-Frequency (20 kHz) Ultrasonic Modulation of Drug Action.

We tested the effect of low-frequency ultrasound (LUS, 20 kHz, 4 W/cm) on the function of rat mesentery and human pulmonary arteries with wire myography. The vessels were induced to contract with either noradrenaline or physiologic saline solution (PSS) with a high potassium concentration (KPSS) and then incubated with capsaicin (2.1 × 10 M, TRPV1 [transient receptor potential vanilloid 1] activator), dopamine (1 × 10 M, dopamine and α-receptor activator), or fenoldopam (dopamine receptor agonist, 1 × 10 M) with and without glibenclamide (1 μM, KATP [adenosine triphosphate {sensitive potassium channel (ATP)}-sensitive potassium channel] inhibitor and α-receptor modulator), and insonated.

Experimental investigation of the determination for the safe operating regime of ultrasound tube-shaped waveguide wire for internal blood vessel debulking.

Background: Majority of limb amputations are caused by circulatory disturbances such as vascular occlusions and strictures. Discovery of modern and more advanced ultrasonic interventional vascular debulking methodology would likely save limbs of CVD patients and their lives in an economical way. However, there is a lack of researches regarding the ultrasound's effect on physiological functions of human blood cells.

Adaptation of cardiovascular system stent implants.

Time-consuming design and manufacturing processes are a serious disadvantage when adapting human cardiovascular implants as they cause unacceptable delays after the decision to intervene surgically has been made. An ideal cardiovascular implant should have a broad range of characteristics such as strength, viscoelasticity and blood compatibility. The present research proposes the sequence of the geometrical adaptation procedures and presents their results.

Influence of low-frequency vibrations on blood flow improvement in human's limbs.

The fundamental cause of diabetic limbs' problem is insufficient blood supply. The aim of the current work was to experimentally and numerically investigate the blood flow velocity and pressure changes in the channel during vibrational excitation. The micro-scale Particle Image Velocimetry (μPIV) technique as well as corresponding numerical channel model in COMSOL Multiphysics software were used to investigate the influence of external vibrations.