Publications by authors named "Mantao Liu"
Mol Biol Cell
December 2005
Article Synopsis
- Ras mutations lead to altered tight junctions in epithelial cells, causing specific increases in permeability to certain solutes like D-mannitol and polyethylene glycol.
- While transepithelial electrical resistance rises, indicating changes in ion permeability, there’s a "ceiling" on solute size that can cross the barrier, suggesting no loss of cells or junctions, despite changes in claudin levels.
- The changes in permeability and tight junction composition may impact tumor growth, as they allow different solutes to pass through the epithelial barrier, possibly influencing cancer progression.
