To Investigate the Involvement of Mast Cells in the Pathogenesis of Oral Lichen Planus and Oral Lichenoid Reactions.

Aim: Role of mast cells in the development of oral lichen planus (OLP) and oral lichenoid reactions (OLR).

Material And Methods: The tissue slices used in this investigation were obtained from the archives of the Department of Oral Pathology and were formalin-fixed and embedded in paraffin. The sections were obtained from 40 cases of OLP that were identified by histological examination, as well as 40 cases of OLR.

Assessment of Expression of Mast Cells Density in Oral Premalignant and Malignant Lesions by Histochemical Analysis.

Aim: Assessment of mast cells density expression in oral premalignant and malignant lesions by histochemical analysis.

Materials And Methods: The study used a total of 120 tissue blocks that were formalin-fixed and paraffin-embedded. These blocks consisted of 40 cases of oral squamous cell carcinoma (OSCC), 40 cases of oral epithelial dysplasia, and 40 cases of normal oral mucosa (NOM).

Haploidentical Hematopoietic Cell Transplantation in Dyskeratosis Congenita with Myelodysplastic Syndrome/Acute Myeloid Leukemia.

Background: Allogeneic hematopoietic cell transplantation (Allo-HCT) is the only curative option for marrow failure, myelodysplastic syndrome (MDS), and acute myeloid leukemia associated with dyskeratosis congenita (DKC). Due to chromosomal instability and sensitivity to radiation and alkylating agents, HCT is associated with a high incidence of transplant-related mortality in DKC.

Case Report: A 25-year-old male presented with DKC-associated cutaneous manifestations and myelodysplastic syndrome / acute myelogenous leukemia (MDS/AML).

Comparison of Standard and Global Coagulation Tests in Hemodialysis Patients.

Background: Chronic kidney disease (CKD) is associated with an increased tendency of bleeding and thrombosis. There are multiple factors that interact with each other to cause either in CKD patients. Conventional or standard coagulation tests (SCT) have several limitations.

Hypoxia-Responsive Polymersomes for Stemness Reduction in Patient-Derived Solid Tumor Spheroids.

Aggressive solid tumors are associated with rapid growth, early hypoxia, a lack of targeted therapies, and a poor prognosis. The hypoxic niches within the rapidly growing solid tumors give rise to a stem-cell-like phenotype with higher metastasis and drug resistance. To overcome the drug resistance of these regions, we used hypoxia-responsive polymersomes with an encapsulated anticancer drug (doxorubicin, Dox) and a stemness modulator (all-trans retinoic acid, ATRA).

Brainstem Hemorrhage After Extradural Hematoma Evacuation: Myth or Truth?

Brainstem hemorrhage can occur as a primary or secondary event in traumatic brain injury (TBI). Duret hemorrhage is a type of brainstem hemorrhage caused by a secondary increase in intracranial pressure and transtentorial herniation. Duret hemorrhage following TBI has been considered an irreversible and terminal event.

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36 TeV with the ATLAS Detector at the LHC.

This Letter presents a search for highly ionizing magnetic monopoles in 262  μb^{-1} of ultraperipheral Pb+Pb collision data at sqrt[s_{NN}]=5.36  TeV collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion data.

Local structural flexibility drives oligomorphism in computationally designed protein assemblies.

Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. Although computational methods for designing novel self-assembling proteins have advanced substantially over the past decade, they primarily focus on designing static structures. Here we characterize three distinct computationally designed protein assemblies that exhibit unanticipated structural diversity arising from flexibility in their subunits.

Fluorescent p53 helix mimetics pairing anticancer and bioimaging properties.

Fluorescent therapeutic molecules offer a unique platform to study cellular uptake and biological pathways of drug candidates. Inhibition of the p53-HDM2 protein complex with the reactivation of the p53 pathway leading to apoptosis is a promising way to overcome the barriers and challenges in cancer therapeutic design. Although p53 helix mimetics based on the 'hotspots' design using either helical or non-helical backbones are known, cell-permeable and biocompatible inherently fluorescent helix mimetics have not yet been described.

Understanding the Solution-Phase Catalysis Process inside the Li-O Battery Using Redox Mediator─Butylated Hydroxytoluene.

The redox mediators help prevent cathode passivation and promote the formation and decomposition of LiO within the electrolyte of the battery. Understanding the mechanistic properties of the soluble catalyst from an atomic level is crucial for developing an all-in-one multifunctional soluble catalyst for Li-O batteries. With the help of density functional theory and atom-centered density matrix propagation molecular dynamics simulations, we report how butylated hydroxytoluene (BHT), an experimentally reported soluble catalyst, mediates the stabilization of reactive intermediates and the mechanism behind the formation and decomposition of LiO.

N-doped graphene oxide nanomaterial: synthesis and application as controlled-release of urea for advancement in modern agriculture.

Controlled-release fertilizer plays a crucial role in advancing modern agriculture. One promising avenue of research is the utilization of graphene oxide (GO) for controlled-release fertilizer. Here, urea decorated GO (urea@GO) nanomaterial has fabricated through mechanical process and applied for enhance the releasing characteristics of urea by control study.

Ecosense: a revolution in urban air quality forecasting for smart cities.

The Smart City (SC) framework is popular due to its advancement in enhancing lives and public safety. However, these advancements lead to many challenges due to the dependency of Internet of Things (IoT) devices in terms of electronic waste and resource consumption. To address those challenges, the integration of a weather-smart grid (WSG) with SC becomes crucial to safeguard the environment and residents' well-being.

Finerenone in the management of diabetes kidney disease.

People with type 2 diabetes are at risk of developing progressive diabetic kidney disease (DKD) and end stage kidney failure. Hypertension is a major, reversible risk factor in people with diabetes for development of albuminuria, impaired kidney function, end-stage kidney disease and cardiovascular disease. Slowing progression of kidney disease and reducing cardiovascular events can be achieved by a number of means including the targeting of blood pressure and the use of specific classes of drugs The use of Renin Angiotensin Aldosterone System (RAAS) blockade is effective in preventing or slowing progression of DKD and reducing cardiovascular events in people with type 2 diabetes, albeit differently according to the stage of DKD.

B Lineage Acute Lymphoblastic Leukemia with concurrent and rearrangements - An Entity with Dismal Outcome.

Unlabelled: The rearrangement, an uncommon cytogenetic abnormality linked to -like B-ALL, is often underdiagnosed due to the absence of a robust testing strategy, especially in resource-constrained settings. We report six cases of B-ALL with concurrent and rearrangement from India, representing 1.3% of the tested cases, and reviewed the existing literature.

Microkinetic Modelling of Electrochemical Oxygen Evolution Reaction on Ir(111)@N-Graphene Surface.

We have explored the thermodynamics and microkinetic aspects of oxygen evolution catalysis on low loading of Ir(111) on nitrogen-doped graphene at constant potential. The electronic modification induced by N-doping is the reason for the reduced overpotential of OER. The N-induced defect in the charge density is observed with increasing charge-depleted region around the Ir atoms.

Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal).

Background: Three million babies die in the early neonatal period while 2.6 million are stillborn per year worldwide, and one of three deaths can be prevented. The perinatal mortality rate in Nepal is around 31 per 1000 births.

ONUBAD: A comprehensive dataset for automated conversion of Bangla regional dialects into standard Bengali dialect.

Despite significant research on the Bangla language in Natural Language Processing (NLP), there remains a notable resource deficit for its diverse regional dialects, such as those spoken in Chittagong, Sylhet, and Barisal. These dialects, often considered unintelligible to speakers of Standard Bengali, pose challenges due to their unique grammatical structures and phonetic variations. Some linguists categorize them as distinct languages.

or Who Caused the Diarrhea?

Cyclospora cayetanensis, a parasite causing human enteritis, has been rarely reported from healthcare laboratories despite its universal presence. While it is usually responsible for self-limiting diarrhea in immunocompetent individuals, we present a case where the patient suffered from severe, unrelenting diarrhea despite having no obvious immune defects. Additionally, there was no history of international travel or consumption of outside food or water.

Rational pore engineering reveals the relative contribution of enzymatic sites and self-assembly towards rapid ferroxidase activity and mineralization: impact of electrostatic guiding and cage-confinement in bacterioferritin.

The self-assembled ferritin protein nanocage plays a pivotal role during oxidative stress, iron metabolism, and host-pathogen interaction by executing rapid iron uptake, oxidation and its safe-storage. Self-assembly creates a nanocompartment and various pores/channels for the uptake of charged substrates (Fe) and develops a concentration gradient across the protein shell. This phenomenon fuels rapid ferroxidase activity by an upsurge in the substrate concentration at the catalytic sites.

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.

Ultranarrow Semiconductor WS Nanoribbon Field-Effect Transistors.

Semiconducting transition metal dichalcogenides (TMDs) have attracted significant attention for their potential to develop high-performance, energy-efficient, and nanoscale electronic devices. Despite notable advancements in scaling down the gate and channel length of TMD field-effect transistors (FETs), the fabrication of sub-30 nm narrow channels and devices with atomic-scale edge control still poses challenges. Here, we demonstrate a crystallography-controlled nanostructuring technique to fabricate ultranarrow tungsten disulfide (WS) nanoribbons as small as sub-10 nm in width.

Assessment of different U-Net backbones in segmenting colorectal adenocarcinoma from H&E histopathology.

Adenocarcinoma, the most prevalent type of colorectal cancer, makes up roughly 95 % of all cases and is associated with a notably high mortality rate. Owing to the various risk factors which might include personal choices and habits or genetic factors, the risk of developing the cancer for every individual might vary. However, given the statistics, the rate of acquiring the disease is pretty high.

Isolation, structural characterization of (1 → 4), (1 → 6)-α-D-glucan from Dioscorea Alata and synthesis and catalytic activity studies of (1 → 4), (1 → 6)-α-D-glucan derived carbon dots.

Herein, a straightforward, productive protocol was adopted for the synthesis of carbon dots (CDs) by a simple microwave-assisted technique from (1 → 4), (1 → 6)-α-D-glucan polysaccharide (DAPS). The isolation and structural characterization of (1 → 4), (1 → 6)-α-D-glucan from the aqueous extracting of the Diascorea Alata was described here. The photo-physical and morphological studies of the prepared high quantum yield (27.

Mitochondrial Complex I and ROS control synapse function through opposing pre- and postsynaptic mechanisms.

Neurons require high amounts energy, and mitochondria help to fulfill this requirement. Dysfunctional mitochondria trigger problems in various neuronal tasks. Using the neuromuscular junction (NMJ) as a model synapse, we previously reported that Mitochondrial Complex I (MCI) subunits were required for maintaining NMJ function and growth.