Correlates of Lifestyle Physical Activity Among Young Arab American Women.

Background: Young Arab American women are at risk for cardiovascular disease, but there is limited data on their physical activity (PA) engagement.

Objectives: The aim of this study was to examine the relationship between PA and its correlates in young Arab American women. The objectives of this study were to: (1) describe self-reported lifestyle PA behaviors of young Arab American women and (2) examine the relationship between their self-reported lifestyle PA, device-measured lifestyle PA (combined moderatevigorous and steps), and potentially associated factors (demographics, physical measures, individual factors, and behavior cognition factors).

Comparison of Surgical Techniques for Correction of Mandibular Asymmetry in TMJ Ankylosis Patients.

Background: Temporomandibular joint (TMJ) ankylosis frequently results in mandibular asymmetry, which impairs an affected person's ability to function and look good. Because of the intricacy of TMJ ankylosis and the variety of surgical procedures available, correcting mandibular asymmetry surgically can be difficult.

Methods: Patients with mandibular asymmetry and TMJ ankylosis who had surgery at a tertiary care facility between certain periods were the subject of a retrospective investigation.

Assessment of Temporomandibular Joint Disorders: Retrospective Study of Clinical Presentations.

Objective: This retrospective research aimed to assess the clinical presentations and management strategies for "temporomandibular joint (TMJ)" disorders.

Methods: Medical records of patients diagnosed with TMJ disorders between 2017 and 2022 were retrospectively analyzed. Data collected included demographic information, clinical symptoms, radiographic findings, treatment modalities, and treatment outcomes.

Analysis of Long-Term Success and Biological Complications in Zygomatic Implant-Supported Prostheses.

Introduction: Patients with significant maxillary atrophy who are not candidates for standard implants now have an option thanks to zygomatic implants. Long-term statistics on difficulties and success are, however, scarce.

Methods: A tertiary care center's patient data were retrospectively analyzed.

Assessment of Long-Term Effects and Patient Satisfaction following TMJ Disc Replacement Surgery.

Objectives: The purpose of this research is to evaluate patient satisfaction and long-term consequences after temporomandibular joint (TMJ) disc replacement surgery in a tertiary care environment.

Methods: 500 patients who had TMJ disc replacement surgery at a tertiary care facility between 2010 and 2015 were the subject of a retrospective investigation. Pre-operative clinical features, demographic information, and intraoperative information were gathered.

The swallowing and speech after transoral robotic surgery-does the site impact the outcome?

Transoral robotic surgery (TORS) has been introduced to head and neck surgery as a minimally invasive techqniques to improve the functional outcomes of patients. Compare the functional outcome for swallowing and speech in each site of TORS within the head and neck. Retrospective cohort study for patients who underwent TORS within the head and neck unit.

Cell membrane proteome analysis in HEK293T cells challenged with α-synuclein amyloids.

Amyloids interact with plasma membranes. Extracellular amyloids cross the plasma membrane barrier. Internalized extracellular amyloids are reported to trigger amyloidogenesis of endogenous proteins in recipient cells.

Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium.

Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals.

Detecting labile heme and ferroptosis through 'turn-on' fluorescence and lipid droplet localization post Fe sensing.

Iron, a crucial biologically active ion essential for metabolic processes in living organisms, plays a vital role in biological functions, and imbalances in iron levels can lead to various diseases. In this study, we have developed two simple "turn-on" fluorescent probes, NOPy and NOCN, for the quick and selective detection of Fe at nanomolar levels (LOD of 35 nM), accompanied by significant absorption and emission shifts, along with colorimetric demarcation. Both fluorophores exhibit an excellent "turn-on" emission response upon encountering Fe in the cells.

A multipurpose mitochondrial NIR probe for imaging ferroptosis and mitophagy.

This paper explores the use of a di-cationic fluorophore for visualizing mitochondria in live cells independent of membrane potential. Through the synthesized di-cationic fluorophore, we investigate the monitoring of viscosity, ferroptosis, stress-induced mitophagy, and lysosomal uptake of damaged mitochondria. The designed fluorophore is based on DQAsomes, cationic vesicles responsible for transporting drugs and DNA to mitochondria.

Evaluating the Long-Term Outcomes of Periodontal Surgery vs. Non-Surgical Treatment in Aggressive Periodontitis.

Background: Aggressive periodontitis is a severe form of periodontal disease characterized by rapid tissue destruction and tooth loss. The optimal treatment approach for managing this condition remains a topic of debate.

Materials And Methods: A retrospective cohort study was conducted, involving patients diagnosed with aggressive periodontitis who received either surgical or non-surgical treatment between 2010 and 2020.

Comparing the efficacy of fluconazole and cryotherapy Versus cryotherapy alone on treating cutaneous leishmaniasis: a triple-blind randomized clinical trial.

Objective: Cutaneous Leishmaniasis (CL) is one of the highly prevalent endemic diseases in the Middle East. The disease is a complex skin infection imposing a heavy burden on many developing countries. This study aimed to evaluate the impact of adding oral fluconazole to topical cryotherapy on the treatment efficacy and time to achieve complete recovery of CL lesions.

Widespread nuclear lamina injuries defeat proteostatic purposes of α-synuclein amyloid inclusions.

Biogenesis of inclusion bodies (IBs) facilitates protein quality control (PQC). Canonical aggresomes execute degradation of misfolded proteins while non-degradable amyloids sequester into insoluble protein deposits. Lewy bodies (LBs) are filamentous amyloid inclusions of α-synuclein, but PQC benefits and drawbacks associated with LB-like IBs remain underexplored.

A two-in-one probe: imaging lipid droplets and endoplasmic reticulum in tandem.

The endoplasmic reticulum (ER) and lipid droplets (LDs) intricately interact in cellular processes, with the ER serving as a hub for lipid synthesis and LDs acting as storage organelles for lipids. Developing fluorescent probes that can simultaneously visualise the ER and LDs provides a means for real-time and specific visualisation of these subcellular organelles and elucidating their interaction. Herein, we present synthetically simple and novel donor-π-acceptor styryl fluorophores (PFC, PFN and PFB) incorporating pentafluorophenyl (PFP) to demonstrate exquisite discriminative imaging of ER and LD with a single excitation wavelength.

Estimation of the Mechanical Properties of PRF in the Implant Surgery: An Original Research.

Introduction: In many oral procedures that involve the implants, hair implantations, "" is commonly applied. The advantages are many. In this study, the mechanical resistance of PRF under resistance pull on a longitudinal axis was assessed and compared.

Evaluation of the Head and Neck Surgery During the Pandemic COVID-19: A Tertiary Care Center Study.

Introduction: There is a notable shift in the attitude of the admission, review, diagnostics, and follow-up of patients for all the medical sectors and of particular interest of cancer patients. The present study aimed to elaborate on the identification of patients with head and neck cancers (HNCs); the diagnostics, the triage, and the best treatment plan were all evaluated and at the same time compared with the years before the pandemic at a tertiary care center that caters to various other patients also.

Materials And Methods: A retrospective observational clinical study was conducted at the tertiary care center that catered to all the medical specialties.

Comparison of the Quality of Life Among the Immediate Loading Implant Overdentures Using the Single and the Double Implants: An Original Study.

Introduction: In edentulous individuals, single implant-retained mandibular overdentures are an effective substitute for double implant-retained overdentures. In this current research, the oral health-related quality of life (OHRQoL) was assessed for the immediate loading overdenture using the implants. The comparisons are drawn between the single and double implants.

Assessment of the Peri-Implant Conditions for the Primary and the Repeated Abutment Placements: An Original Research.

Introduction: Recurrent abutment substitutions may physically irritate the mucosal (soft tissue) barrier, which may cause additional toxic irritants and germs to enter the mucosal implant barrier and weaken the tissues surrounding implant. The creation of a "definitive abutment" may lessen the likelihood of tissue losses around the implant. Determining the characters of the peri-implant tissue after the placement of the definitive abutments and multiple abutment replacement was the goal of this study.

Assessment of Pain Management After Orthognathic Surgery by the Administration of Montelukast: An Original Research.

Introduction: Opioid may cause undue risk after surgical procedures like orthognathic surgeries. The present study was aimed to determine how the preoperative administration of oral montelukast affected the degree of postoperative discomfort following bimaxillary orthognathic surgery (BOS).

Methodology: This study included all skeletal class III subjects scheduled for BOS.

A dengue vaccine whirlwind update.

Dengue virus (DENV) is a mosquito-borne single-stranded RNA virus of the family with four serotypes (DENV1, DENV2, DENV3, and DENV4) circulating many tropical and subtropical regions of the world. Endemic in more than 100 countries, DENV results in over 400 million cases annually, a subset presenting with severe or life-threatening illnesses such as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). While no specific treatments outside of supportive management exist, vaccines are an area of major research with two vaccines, Dengvaxia (CYD-TDV) and Denvax (TAK003), recently licensed for clinical use.

Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases.