Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-'-Arylaminophenothiazines.

The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-'-arylaminophenothiazines and asymmetrical 3,7-di('-arylamino)phenothiazines. This approach included the optimization of synthetic strategy by quantification analysis of the positive charge distribution in the cation of 3-'-arylaminophenothiazine derivative.