Human Wharton's jelly mesenchymal stem cells-derived secretome could inhibit breast cancer growth and .

Objectives: Controversial results have been reported regarding the anti-tumor properties of extracellular vesicles derived from mesenchymal stem cells (MSCs). The present study was conducted to evaluate whether secretome derived from Human Wharton's jelly mesenchymal stem cells (hWJMSCs) may stimulate or inhibit breast cancer growth and .

Materials And Methods: MTT assays was performed to determine anti-tumor effects of hWJMSCs-secretome on both MCF-7 and 4T1 tumor cells .

Assessment of Cytokine Expression Profile of MCF-7 Cells in Response to hWJ-MSCs Secretome.

Several attempts have been made to identify the mechanisms by which mesenchymal stem cells (MSCs)-derived secretome exert anti-tumor or tumorigenic effects, but still further investigations are needed to explore this subject. Thus, in this study we want to examine the expression of different cytokines in secretome of hWJ-MSCs and their effects on cytokine expression profile of the MCF-7 tumor cells. The hWJ-MSCs were isolated and characterized according to the International Society for Cellular Therapy criteria.

An anticancer effect of umbilical cord-derived mesenchymal stem cell secretome on the breast cancer cell line.

Nowadays, Mesenchymal stem cells (MSCs) have become one of the most attractive tools for treating tumors, due to their specific characteristics, the most prominent of which are tropism toward tumor. These cells will exert their effects through their secretion. In this study, our aim was to evaluate the anti-cancer effect of umbilical cord-derived mesenchymal cells (UCMSC) secretome, on MCF-7 tumor cells.

Evaluation of intima media thickness of carotid arteries in 40-60 years old persons with type d personality and its comparison with normal ones.

Background: In some studies, the involvement of dangerous psychological and behavioral factors in etiology and physiotherapy of vascular disturbances have been shown. In other studies, the relationship between the personality type and increase in cardiovascular disease has been demonstrated. The type D personality is defined as having two characteristics of negative affect and social inhibition.

Effectiveness of Attribution Retraining on Women's Depression and Anxiety After Miscarriage.

Background: Given miscarriage psychological consequences on the women health, the aim of the present study is the survey of effectiveness rate of attributive retraining interventions on women depression and anxiety reducing after miscarriage.

Methods: The present study is semi-empiric and it's made using control group, pre- and post-test execution and follow-up. Thirty-two women, who had recent experience of miscarriage, were selected among female referents to obstetricians and clinics in Esfahan city by accessible sampling and then they were placed on two groups, case and control, randomly.