Effect of a polyherbal Unani formulation on left ventricular diastolic dysfunction in hypertensive patients - a randomized single blind placebo controlled clinical trial.

Objectives: Diastolic dysfunction represents an important pathophysiological intermediate between hypertension and heart failure. In the last two decades, the prevalence of heart failure patients having normal or near normal ejection fraction (EF) has increased to around 60 %. It thus poses a great morbidity and mortality risk to the population.

Biotechnological Tools to Elucidate the Mechanism of Plant and Nematode Interactions.

Plant-parasitic nematodes (PPNs) pose a threat to global food security in both the developed and developing worlds. PPNs cause crop losses worth a total of more than USD 150 billion worldwide. The sedentary root-knot nematodes (RKNs) also cause severe damage to various agricultural crops and establish compatible relationships with a broad range of host plants.

Nemato-toxic analysis of several chopped plant leaves against Meloidogyne incognita affecting tomato In vitro and In pots.

Tomato plant is affected by several pathogens, including root-knot nematodes (RKNs), belonging to the genus Meloidogyne. Meloidogyne incognita is among the most potent pests infecting tomato roots. Therefore, it is of interest to discuss the management of Meloidogyne incognita using selected botanicals such as Cammelina benghalensis, Evolvulus nummularius, Gomphrena celosioides, Lindenbergia indica, Scoparia dulcis and Vernonia cinerea.

A robust fluorescence-based assay for human erythrocyte Ca efflux suitable for high-throughput inhibitor screens.

Intracellular calcium is maintained at very low concentrations through the action of PMCA Ca extrusion pumps. Although much of our knowledge about these Ca extrusion pumps derives from studies with human erythrocytes, kinetic studies of Ca transport for these cells are limited to radioisotope flux measurements. Here, we developed a robust, microplate-based assay for erythrocyte Ca efflux using extracellular fluorescent Ca indicators.

Efficacy of Jawarish Shahi a herbal formulation in irritable bowel syndrome: An open-labeled single-arm clinical trial.

Background And Aim: Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders characterized by chronic recurrent abdominal pain related to a change in bowel habit or defecation frequency and commonly accompanied by anxiety and depression affecting about 10% population globally. Jawarish Shahi (JS) is a special dosage form prepared for gastrointestinal disorders in Unani medicine containing L., Retz.

Biological Synthesis of Silver Nanoparticles and Prospects in Plant Disease Management.

Exploration of nanoparticles (NPs) for various biological and environmental applications has become one of the most important attributes of nanotechnology. Due to remarkable physicochemical properties, silver nanoparticles (AgNPs) are the most explored and used NPs in wide-ranging applications. Also, they have proven to be of high commercial use since they possess great chemical stability, conductivity, catalytic activity, and antimicrobial potential.

Root-Knot Disease Suppression in Eggplant Based on Three Growth Ages of .

This investigation presents a novel finding showing the effect of culture filtrates (CFs) of macrofungi, , against evaluated in vitro and in planta. To determine the nematicidal activity, juveniles of were exposed to CFs of three different ages (Two, four and eight weeks old) of pileus and stipe at different concentrations, i.e.

Green Nanotechnology: Plant-Mediated Nanoparticle Synthesis and Application.

The key pathways for synthesizing nanoparticles are physical and chemical, usually expensive and possibly hazardous to the environment. In the recent past, the evaluation of green chemistry or biological techniques for synthesizing metal nanoparticles from plant extracts has drawn the attention of many researchers. The literature on the green production of nanoparticles using various metals (i.

Effect of Individual, Simultaneous and Sequential Inoculation of and on Growth, Biochemical, Enzymatic and Nonenzymatic Antioxidants of Tomato ( L.).

This study was conducted on tomato ( cv. K-21) to investigate the bioprotective nature of and its interactive effects with in terms of growth biomarkers, changes in biochemical attributes and modulation in antioxidant enzymes of the tomato plant. In this study, we grew tomato plants with and in separate pots, simultaneously and sequentially (15 days prior or post) after 15 days of seed sowing.

Click Chemistry for Imaging Protein Palmitoylation during the Asexual Stages of .

Palmitoylation refers to the modification of the cysteine thiols in proteins by fatty acids, most commonly palmitic acid, through 'thioester bond' formation. , palmitoylation of proteins is catalyzed by palmitoyl acyltransferases (PATs or DHHC-PATs). Palmitoylation has recently emerged as a crucial post-translational modification in malarial parasites.

Efficacy of Khār-i-khasak ( Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial.

Background: Prehypertension is a state of above-normal blood pressure that does not meet the criteria for the diagnosis of hypertension and its prevalence estimated in population-based samples ranges from 22 to 52%. It conveys potentially many deleterious consequences such as high risk of progression to hypertension and cardiovascular disease later in life.

Objectives: The present study was conducted to evaluate the blood pressure-lowering effect of Khār-i-khasak ( Linn.

Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Merozoites.

Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, . S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation is regulated by concerted activities of DHHC palmitoyl acyl transferases (DHHC PATs) and acyl protein thioesterases (APTs), which are enzymes responsible for protein palmitoylation and depalmitoylation, respectively.

Calcium-dependent phosphorylation of serine repeat antigen 5 triggers merozoite egress.

The human malaria parasite proliferates in red blood cells following repeated cycles of invasion, multiplication, and egress. serine repeat antigen 5 (PfSERA5), a putative serine protease, plays an important role in merozoite egress. However, regulation of its activity leading to merozoite egress is poorly understood.

Inferior vena cava thrombosis in a pediatric patient of amebic liver abscess.

Amebic liver abscess (ALA) in pediatric age group is rare. We describe a successful thrombectomy and open drainage of a large left lobe ALA associated with thrombus in the hepatic veins and inferior vena cava extending into the right atrium in a 6-year-old boy.

Biofunctionalization of nanoparticle assisted mass spectrometry as biosensors for rapid detection of plant associated bacteria.

This study is based on the application of matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) as biosensor to detect the plant associated bacteria (PAB) isolates from rhizospheric soil and root. The rapid bacterial detection via on particle ionization/enrichment technique using IgG functionalized Pt NPs (IgG-Pt NPs) assisted MALDI-TOF MS was successfully used to explore two PAB isolates, namely, Bacillus thuringiensis and B. subtilis from rhizospheric soil and roots of carrot plant.