Publications by authors named "Mansi Sarihan"
Importance: Scoring systems for Stevens-Johnson syndrome and epidermal necrolysis (EN) only estimate patient prognosis and are weighted toward comorbidities and systemic features; morphologic terminology for EN lesions is inconsistent.
Objectives: To establish consensus among expert dermatologists on EN terminology, morphologic progression, and most-affected sites, and to build a framework for developing a skin-directed scoring system for EN.
Evidence Review: A Delphi consensus using the RAND/UCLA appropriateness criteria was initiated with a core group from the Society of Dermatology Hospitalists to establish agreement on the optimal design for an EN cutaneous scoring instrument, terminology, morphologic traits, and sites of involvement.
A Case of Disseminated Cutaneous Herpes Simplex Virus-1 as the First Manifestation of Human Immunodeficiency Virus Infection.
J Investig Med High Impact Case Rep
October 2021
Article Synopsis
- Active HSV-1 infection typically causes painful rashes, encephalitis, and rare septic shock; in immunocompromised patients, rashes can spread widely.
- A 33-year-old man with undiagnosed HIV presented with a severe rash covering 90% of his body, initially misdiagnosed as dermatitis.
- Tests confirmed HSV-1 as the cause of the rash, which improved with acyclovir treatment and initiation of antiretroviral therapy.
The XPD(ERCC2) gene encodes a DNA helicase involved in DNA repair and transcription. Patients with mutations in XPD may have different autosomal recessive phenotypes including trichothiodystrophy (TTD) or xeroderma pigmentosum (XP). TTD patients have sulfur-deficient, brittle hair, short stature and developmental delay.
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