Publications by authors named "Manraj Sharma"
Neutrophils are essential for host defense against (). The neuro-repellent, SLIT2, potently inhibits neutrophil chemotaxis, and might, therefore, be expected to impair antibacterial responses. We report here that, unexpectedly, neutrophils exposed to the N-terminal SLIT2 (N-SLIT2) fragment kill extracellular more efficiently.
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- The study compiles health utility values (HUVs) related to breast cancer from various published research articles, focusing on different stages of the disease and treatment options.* -
- Through systematic database searches from 2005 to 2017, researchers analyzed 79 studies, identifying significant differences in HUVs between early and advanced breast cancer patients and noting that treatment methods like chemotherapy linked to lower utility scores.* -
- The findings highlight notable variability in study populations and methodologies, stressing the need for consistency in measuring HUVs to better evaluate the effectiveness of breast cancer interventions.*
Kidney transplantation with grafts procured after donation-after-cardiac death (DCD) has led to an increase in incidence of delayed graft function (DGF). It is thought that the warm ischemic (WI) insult encountered during DCD procurement is the cause of this finding, although few studies have been designed to definitely demonstrate this causation in a transplantation setting. Here, we use a large animal renal transplantation model to study the effects of prolonged WI during procurement on post-transplantation renal function.
View Article and Find Full Text PDFUnlabelled: Normothermic ex vivo kidney perfusion (NEVKP) has demonstrated superior outcomes for donation-after-cardiovascular death grafts compared with static cold storage (SCS). To determine the mechanisms responsible for this, we performed an unbiased genome-wide microarray analysis.
Methods: Kidneys from 30-kg Yorkshire pigs were subjected to 30 min of warm ischemia followed by 8 h of NEVKP or SCS, or no storage, before autotransplantation.