Publications by authors named "Manqing Tang"
Acta Pharm Sin B
August 2024
Article Synopsis
- * The review discusses how CTCs form and their mechanisms for spreading cancer, including their interactions with signaling pathways and platelets.
- * It highlights the importance of advanced nanomedicine strategies aimed at targeting CTC survival methods to improve outcomes in metastatic cancer therapies.
Eur J Pharm Biopharm
October 2024
Article Synopsis
- Activating the cGAS-STING pathway in circulating tumor cell clusters (CTC clusters) could help reduce metastasis in cancer treatment.
- Researchers developed a nanoparticle (NP) called PLTs@Pt-lipid@lomi, which combines cholesterol-modulating agent lomitapide with MCL-miriplatin to enhance its effectiveness and penetration into CTC clusters.
- This innovative NP not only efficiently activates the STING pathway and reduces CTC stemness, but also outperforms free lomitapide, ultimately leading to decreased metastasis in a post-surgery animal model.
