Publications by authors named "Manqi Liu"
Article Synopsis
- The study aimed to investigate how electroacupuncture at the "Fenglong" point affects specific proteins related to cholesterol metabolism in rats with high cholesterol levels, focusing on AMPK and mTOR pathways.
- The experiment involved dividing 30 male rats into five groups, with some receiving electroacupuncture and others specific drug treatments to evaluate the impact on their cholesterol levels over a month.
- Blood lipid levels and liver tissue morphology were assessed through biochemical tests and staining techniques to understand the effects of the treatments on hyperlipidemia.
Diabetic cardiomyopathy (DCM) is a heart failure syndrome, and is one of the major causes of morbidity and mortality in diabetes. DCM is mainly characterized by ventricular dilation, myocardial hypertrophy, myocardial fibrosis and cardiac dysfunction. Clinical studies have found that insulin resistance is an independent risk factor for DCM.
View Article and Find Full Text PDFOGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.
Int Immunopharmacol
January 2024
Article Synopsis
- 8-oxoguanine (8-oxoG) is a DNA lesion caused by reactive oxygen species that leads to genetic instability, and it's recognized by the repair protein OGG1.
- OGG1 plays a dual role in base excision repair and regulates gene expression, particularly during the activation of fibroblasts in lung fibrosis.
- Increasing OGG1 levels during fibroblast activation enhances pro-fibrotic gene expression in response to bleomycin, suggesting that targeting OGG1 could be a viable therapeutic strategy for treating Idiopathic Pulmonary Fibrosis (IPF).
Background: Observational studies have revealed that a lack of physical exercise may be linked to a higher risk of heart failure (HF). Here, the causal relationship between sedentary behavior (SB) and HF was investigated using Mendelian randomization (MR).
Hypothesis: SB was considered as an important risk factor of HF.
Cardiomyocyte apoptosis caused by fat metabolism disorder plays an essential role in the pathogenesis of diabetic cardiomyopathy (DCM). Apurinic/apyrimidinic endonuclease 1 (APE1) has multiple functions, including regulating redox and DNA repair. However, the role of APE1 in the pathogenesis of DCM remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- - Scarce research has evaluated how residential greenery impacts lipid levels and dyslipidemia in low/middle-income countries, with a study examining 39,259 rural Chinese adults using satellite data for greenness and blood lipid analysis.
- - Findings revealed that higher residential greenness (measured by NDVI) was linked to increased odds of hyperbetalipoproteinemia, lower total cholesterol, and higher levels of both LDL and HDL cholesterol, particularly in males.
- - The associations were partially influenced by reduced air pollution and lower body mass index (BMI), highlighting the need for further longitudinal studies to establish causal relationships.