One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial.

Background: Retinol, a precursor of retinoic acid, has great potentials as a topical anti-aging molecule; however, only a handful of clinical investigations have been published to date.

Objective: This study aimed to assess the efficacy and safety of 0.1% stabilized retinol on photodamaged skin during a one-year treatment.