Publications by authors named "Manphool Singhal"

Pulmonary sclerosing pneumocytoma is a rare benign neoplasm typically seen in middle-aged women. The exact preoperative diagnosis is quite challenging considering its nonspecific clinical and radiologic features along with complex histology. Moreover, obtaining an exact histopathological diagnosis can be difficult especially with the small biopsy specimens.

View Article and Find Full Text PDF

A 25-year-old man reporting weight loss and constitutional symptoms was empirically treated for tuberculosis. Following acute seizures, the patient underwent cerebral imaging and was diagnosed with multiple nonischemic cerebral lesions. Thoracic imaging revealed fibrosing mediastinitis infiltrating and obscuring the left atrium and left ventricle.

View Article and Find Full Text PDF
Article Synopsis
  • Hypertrophic cardiomyopathy (HCM) is a heart condition where the heart muscle thickens, with apical HCM being a rarer form that affects specific regions of the heart.
  • Traditional echocardiography can make diagnosing apical HCM difficult, leading to cases where patients are referred for CT coronary angiography.
  • The study presents four cases where CT scans not only ruled out coronary artery disease but also helped confirm apical HCM through detailed evaluation of the CT data.
View Article and Find Full Text PDF
Article Synopsis
  • Total anomalous pulmonary venous connection (TAPVC) is a condition where all pulmonary veins drain into the systemic circulation instead of the heart, specifically the right atrium, which is uncommon.
  • A case study of a 10-year-old boy highlighted an unusual instance of TAPVC where the pulmonary veins directly connected to the right atrium without the usual features of right atrial isomerism, and with a normal coronary sinus.
  • Advanced imaging showed a rare combination of additional anomalies, including absence of lung fissures, a unique aortic arch formation, and skeletal abnormalities like cervical ribs and vertebral fusion, which have not been documented together before in relation to TAPVC.
View Article and Find Full Text PDF

Background: Only limited information exists regarding the epidemiology of Kawasaki disease (KD) in low-income and middle-income countries. The present study provides the incidence of KD during 2015-2019 in Chandigarh, north India. Our centre follows the largest KD cohort in India.

View Article and Find Full Text PDF

Introduction: Microvasculopathy and endothelial dysfunction play important roles in the development of post-transplant complications, including graft-versus-host disease (GVHD). We assessed structural microvasculopathy by employing nailfold video capillaroscopy (NFVC) and endothelial dysfunction via flow-mediated dilatation (FMD) of the brachial artery in recipients of hematopoietic stem cell transplantation.

Patients And Methods: Recipients of stem cell transplantation were included in this study post day+100 and divided into two cohorts.

View Article and Find Full Text PDF
Article Synopsis
  • Transthoracic echocardiography (TTE) is commonly used for evaluating coronary artery lesions in children with Kawasaki disease (KD), but this study found it to be less effective than computed tomography coronary angiography (CTCA).
  • In a 9-year study of 225 children with KD, CTCA identified coronary artery lesions in 41 patients (18.2%), while TTE only detected lesions in a third of those cases (36.6%).
  • The findings suggest that CTCA is a more reliable imaging option for assessing coronary artery involvement in KD, which could influence treatment and monitoring strategies.
View Article and Find Full Text PDF

There is evidence to suggest that M-type phospholipase A2 (PLA2R) antibodies activate the mannose-binding lectin (MBL) cascade, resulting in glomerular damage and proteinuria in patients with primary membranous nephropathy (PMN). Furthermore, there are few reports indicating that aberrant MBL activation is associated with endothelial dysfunction and accelerated atherosclerosis. While PMN is a common cause of adult nephrotic syndrome, and patients are at increased risk of cardiovascular disease (CVD), there is a lack of research that explores the factors that contribute to this condition.

View Article and Find Full Text PDF

Detecting cardiac sarcoidosis; a potentially life-threatening condition is challenging and requires a multimodality imaging approach using echocardiography, PET/CT and CMR. Although 18F-FDG is the recommended PET tracer for evaluating cardiac sarcoidosis, it is limited by physiological cardiac FDG uptake and requires stringent patient preparation/ dietary modifications before imaging. We hereby present a case of cardiac sarcoidosis demonstrating myocardial FAPI uptake on cardiac PET, highlighting the potential role of 68Ga-FAPI PET in the evaluation of cardiac sarcoidosis.

View Article and Find Full Text PDF