Synthesis, delivery, and molecular docking of fused quinolines as inhibitor of Hepatitis A virus 3C proteinase.

It is widely accepted that Hepatitis A virus (HAV) is responsible for liver failure and even death in older people and in people with other serious health issues; so, proposing new compounds with inhibitory activity can help to treated of these disease's. In current study, a new class of quinolines is proposed with inhibitor activity of the HAV proteinase. So, in the first step, fused quinoline derivatives has been synthesized in short reaction time (12.

Ag-Catalyzed Multicomponent Synthesis of Heterocyclic Compounds: A Review.

The investigation of the procedures for the multi-component synthesis of heterocycles has attracted the interest of organic and medicinal chemists. The use of heterogeneous catalysts, especially transition metal catalysts in organic synthesis, can provide a new, improved alternative to traditional methods in modern synthetic chemistry. The main focus is on the utilization of silver as a catalyst for the multi-component synthesis of heterocyclic compounds.

Tetramethylguanidine-functionalized melamine as a multifunctional organocatalyst for the expeditious synthesis of 1,2,4-triazoloquinazolinones.

Novel nano-ordered 1,1,3,3-tetramethylguanidine-functionalized melamine (Melamine@TMG) organocatalyst was prepared and adequately identified by various techniques including FTIR, EDX, XRD and SEM spectroscopic or microscopic methods as well as TGA and DTG analytical methods. The Melamine@TMG, as an effective multifunctional organocatalyst, was found to promote smoothly the three-component synthesis of 1,2,4-triazoloquinazolinone derivatives using cyclic dimedone, 3-amino-1,2,4-triazole and different benzaldehyde derivatives in EtOH at 40 °C. This practical method afforded the desired products in high to excellent yields (86-99%) and short reaction times (10-25 min).

Introduction of Succinimide as A Green and Sustainable Organo-Catalyst for the Synthesis of Arylidene Malononitrile and Tetrahydrobenzo[b] pyran Derivatives.

Aim And Objective: In this work, we tried to introduce a non-toxic and stable organic compound named succinimide as a green and efficient organo-catalyst for the promotion of the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives. Using this method led to a clean procedure to achieve these types of bioactive compounds without a specific purification step. The rate and yield of the reactions were excellent, and also succinimide showed acceptable reusability as the catalyst.

Nanoporous Na-Montmorillonite Perchloric Acid as an Efficient and Recyclable Catalyst for the Chemoselective Protection of Hydroxyl Groups.

Nanoporous Na-montmorillonite perchloric acid as a novel heterogeneous reusable solid acid catalyst was easily prepared by treatment of Na-montmorillonite as a cheap and commercially available support with perchloric acid. The catalyst was characterized using a variety of techniques including X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), energy dispersive X-ray spectroscopy (EDX), pH analysis and determination of the Hammett acidity function. The prepared reagent showed excellent catalytic activity for the chemoselective conversion of alcohols and phenols to their corresponding trimethylsilyl ethers with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) at room temperature.

A rapid one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives using Brønsted-acidic ionic liquid as catalyst.

Pyrido[2,3-d]pyrimidine derivatives were synthesized regioselectivly in good to high yields by one-pot three-component condensation of 6-amino-2-(methylthio)pyrimidin-4(3H)-one, aromatic aldehydes and ethylcyanoacetate or meldrum's acid using 1,2-dimethyl-N-butanesulfonic acid imidazolium hydrogen sulfate ([DMBSI]HSO4) Brønsted-acidic ionic liquid as catalyst. Solvent-free mild reaction conditions, short reaction times, easy work-up, and reusability of the catalyst are the main advantages of this protocol.

Facile regioselective synthesis of novel bioactive thiazolyl-pyrazoline derivatives via a three-component reaction and their antimicrobial activity.

A series of novel 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles have been prepared by a three-component cyclo-condensation of various chalcones, thiosemicarbazide and phenacyl bromide. The easy work-up of the products, rapid reaction, and mild conditions are notable features of this protocol. The reaction was efficiently catalyzed in one-pot by a few drops of HCl in EtOH under reflux conditions providing the title compounds in moderate to high yields.

Synthesis and structure-behavior relationships of tetra-substituted imidazole derivatives of 1,3-diazabicyclo[3,1,0]hex-3-ene.

Among photochromic compounds 1,3-diazabicyclo[3.1.0]hex-3-ene derivatives are currently the subject of intense research due to their photochromic behavior particularly in the crystalline state.

An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction.

Novel fused 1H-benzo[f]chromen-indole derivatives were synthesized regioselectivly in good to high yields by triethyl amine catalyzed condensation of 3-cyanoacetylindoles, β-naphthol and aryl aldehydes in methanol under ultrasounic irradiations and conventional conditions. The easy work-up of the products, rapidity, and mild reaction conditions are notable features of this protocol. The antibacterial activity of the selected products was examined.

An efficient one-pot synthesis of new 2-imino-1,3-thiazolidin-4-ones under ultrasonic conditions.

A convenient one-pot protocol was developed for the synthesis of 2-imino-1,3-thiazolidin-4-ones by the reaction of amines, isocyanates, aldehydes, and chloroform in the presence of sodium hydroxide under ultrasonic conditions in high yields (75-91%) and shorter reaction times (12-15 min).

A convenient ultrasound-promoted regioselective synthesis of fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines.

Fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines were obtained in a three-component regioselective reaction of 5-amino-3-methyl-1H-pyrazole, 2H-indene-1,3-dione and arylaldehydes in ethanol under ultrasound irradiation. This rapid method produced the products in short reaction times (4-5min) and excellent yields (88-97%).

An efficient one-pot three-component synthesis of fused 1,4-dihydropyridines using HY-zeolite.

A facile and convenient protocol was developed for the fast (2.5-3.5 h) and high yielding (70-90%) synthesis of fused 1,4-dihydropyridines from dimedone in the presence of HY-zeolite as an efficient recyclable heterogeneous catalyst.

KSF: an efficient catalyst for the regioselective synthesis of 1,5-diaryl pyrazoles using Baylis-Hillman adducts.

A facile and convenient protocol was developed for the regioselective synthesis of 1,5-diarylpyrazoles using Baylis-Hillman adducts over KSF catalyst in high yields (70-90%) and low reaction times.

An efficient ultrasound-promoted synthesis of the Baylis-Hillman adducts catalyzed by imidazole and L-proline.

A convenient protocol was developed for the synthesis of the Baylis-Hillman adducts in the presence of weak Lewis base and l-proline at room temperature under ultrasound irradiation. This method provided the products in good to high yields (65-90%) and reasonable reaction times.