Escherichia coli sequence type 131 (ST131) is a multidrug-resistant strain with the global dissemination. Biofilm formation-related factors include the most important virulence factors in extra-intestinal pathogenic E. coli (ExPEC) ST131 strains causing infections with treatment-limited subjects.
View Article and Find Full Text PDFBackground: Listeria monocytogenes with a vast range of natural reservoirs is more known for being a food-borne pathogen. Human infections have shown an impact on pregnancy outcomes, so, this study surveyed the frequency of L. monocytogenes infection involving different groups of women.
View Article and Find Full Text PDFDNMT1, as a critical enzyme affecting epigenetics through methylation of DNA cytosine-rich sequences, regulates gene expression. Exterior factors including long-term infections, in this study infection, could change host cells' epigenetics by affecting gene expression. This study investigated the statistical correlation between virulence genes and gene expression in gastric antral epithelial cells of gastric adenocarcinoma and gastritis patients.
View Article and Find Full Text PDFCan J Gastroenterol Hepatol
September 2022
Background: and genes contribute to the cell cycle during proliferation and apoptosis, respectively. Designing a case-control study including gastric adenocarcinoma and gastritis patients with and without infection would lead to determinate of the correlations between and genes expression with infection in gastric antral epithelial cells.
Methods: Overall, 50 and 30 gastric antral biopsy samples of gastric cancer (case group) and gastritis (control group) patients were included into study, respectively.
Uropathogenic Escherichia coli (UPEC) strains are the most common cause of urinary tract infection (UTI) in hospitalized and community patients. The aim was to compare the genetic characteristics of E. coli isolated from inpatients (IPs) and outpatients (OPs) with UTI regarding their phylogenies, virulence traits, and resistance trends.
View Article and Find Full Text PDFBackground: Helicobacter pylori as the causative agent of the most common chronic bacterial infectious disease in human still involves a range of clinical challenging complications. In this meantime, the survey of the interaction between H. pylori virulence genes expression and its consequences on gastric antral epithelial cells is Controversial.
View Article and Find Full Text PDFSirtuins, known as the intracellular acylation enzymes, play a major role in regulating the cell's physiological activities. The relevant studies have shown diversely sirtuin genes expression in various cancers in humans. This study has surveyed the transcription of sirt3, 6, and 7 genes in gastric antral epithelial cells (GAECs) of gastritis and gastric adenocarcinoma patients with and without Helicobacter pylori infection.
View Article and Find Full Text PDFInfect Dis Clin Pract (Baltim Md)
November 2021
Background: The Prex2 protein is a member of the Rac family proteins that belongs to small G proteins with a critical role in cell migration, cell proliferation, and apoptosis through its effects on PI3K cell signaling pathway and phosphatase activity of PTEN protein. The effect of PREX2 gene expression has been shown in some cancer cells. A survey of PREX2 gene expression in gastric antral epithelial cells of gastric cancer patients with Helicobacter pylori various genotypes infection can conduct to better understanding H.
View Article and Find Full Text PDFNeisseria gonorrhoeae is the causative agent of the sexually transmitted disease gonorrhoea. This bacterium infects the epithelial cells of the cervix of women and the urethra of men. However, its disease symptoms in the lower genitalia are found only in a small percentage of people.
View Article and Find Full Text PDFCan J Infect Dis Med Microbiol
February 2021
Introduction: Numerous molecular epidemiology studies have been performed about the frequency of virulence genes in patients with infection so far. This study was conducted to detect transcriptional profile by cDNA of virulence genes in gastric biopsy samples of gastritis and gastric carcinoma patients.
Materials And Methods: In a case-control study, based on the prevalence of gastritis and gastric cancer in Sanandaj city during 2018 and 2019, 23 and 11 gastric antral biopsy samples with infection were collected from gastritis and gastric carcinoma patients by the consecutive and available sampling method.
Background: ZAK protein is a member of the MLK family proteins defined as mediators in the cell cycle. A survey of ZAK gene expression in gastric antral epithelial cells (GAECs) of gastritis and gastric adenocarcinoma patients with Helicobacter pylori genotypes infection can elucidate carcinogenesis of H. pylori genotypes.
View Article and Find Full Text PDFBackground: The correlation of infection with gastritis, peptic ulcer, and gastric cancer has been proven. The aim of this study was to determine the effects of and genotypes of on genes expression of interleukin (IL) -10 and tumor growth factor (TGF) β1 in gastric epithelial cells of patients with gastritis and infection.
Methods: In all, 45 gastric biopsy samples were collected from patients with gastritis and infection admitted to Tohid Hospital in Sanandaj city.
Introduction: The World Health Organization has categorized Helicobacter pylori as a carcinogen for gastric cancer, which causes human mortality worldwide. A number of studies have shown that H. pylori affects cell signaling in gastric epithelial cells and changes the expression of some proteins such as proinflammatory cytokines.
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