A systems serology approach to the investigation of infection-induced antibody responses and protection in trachoma.

Background: Ocular infections with serovars A-C cause the neglected tropical disease trachoma. As infection does not confer complete immunity, repeated infections are common, leading to long-term sequelae such as scarring and blindness. Here, we apply a systems serology approach to investigate whether systemic antibody features are associated with susceptibility to infection.