The CineECG in ischemia localization in ST-elevation (equivalent) acute coronary syndromes.

Aim Of The Study: In this proof of concept study we aimed to visualize and quantify the injury vectors using the CineECG in representative examples of ST elevation acute myocardial infarction (STEMI) and STEMI-equivalent electrocardiograms (ECG's). For this purpose ECG's were selected with different ST deviation patterns in acute anterior wall, inferior or posterolateral wall infarctions.

Methods: The ST-amplitudes of the individual leads were measured between J-point and 60 ms after the J-point.

Body surface potential mapping detects early disease onset in plakophilin-2-pathogenic variant carriers.

Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive inherited cardiac disease. Early detection of disease and risk stratification remain challenging due to heterogeneous phenotypic expression. The standard configuration of the 12 lead electrocardiogram (ECG) might be insensitive to identify subtle ECG abnormalities.

CineECG illustrating the ventricular activation sequence in progressive AV-junctional conduction block.

We present the use of CineECG in visualizing abnormal ventricular activation in a case of a complex conduction disorder. CineECG combines the standard 12‑lead surface ECG with a 3D anatomical model of the heart. It projects the location and direction of the average ventricular activation and recovery on the heart model over time.

Incorporating structural abnormalities in equivalent dipole layer based ECG simulations.

Electrical activity of the myocardium is recorded with the 12-lead ECG. ECG simulations can improve our understanding of the relation between abnormal ventricular activation in diseased myocardium and body surface potentials (BSP). However, in equivalent dipole layer (EDL)-based ECG simulations, the presence of diseased myocardium breaks the equivalence of the dipole layer.

ECG-based techniques to enhance clinical practice in cardiac genetic disease management.

Introduction: Inherited cardiomyopathies are associated with a broad spectrum of potentially lethal phenotypes characterized by structural and electrical myocardial remodeling. Increased awareness and genetic cascade screening lead to more genotype-positive, yet phenotype-negative individuals to be evaluated and followed up. The predictive value of genetic testing is hampered by incomplete penetrance and high variability in disease onset, progression and severity.