Publications by authors named "Manon Gourdelier"
Article Synopsis
- Intracellular bacterial pathogens manipulate host cell processes to create a suitable environment for their survival, with the Q fever bacterium using its Type 4 secretion system to form a specialized vacuole known as a CCV.
- The study identifies that the bacterial effector protein Vice interacts with specific lipids (like phosphatidylserine) and triggers the formation of compartments similar to CCVs in host cells, demonstrating its role in both vacuole formation and stabilization.
- Vice performs dual functions: first aiding in the internalization of vacuoles through macropinocytosis, and then disrupting the ESCRT machinery to maintain these compartments, highlighting its key role in bacterial replication and survival.
Patients with severe COVID-19 show an altered immune response that fails to control the viral spread and suffer from exacerbated inflammatory response, which eventually can lead to death. A major challenge is to develop an effective treatment for COVID-19. NF-κB is a major player in innate immunity and inflammatory process.
View Article and Find Full Text PDFSARS-CoV-2 is an RNA enveloped virus responsible for the COVID-19 pandemic that conducted in 6 million deaths worldwide so far. SARS-CoV-2 particles are mainly composed of the 4 main structural proteins M, N, E and S to form 100 nm diameter viral particles. Based on productive assays, we propose an optimal transfected plasmid ratio mimicking the viral RNA ratio in infected cells.
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