Publications by authors named "Manolis Tsouvalas"
Background: High-sensitivity C-reactive protein (hs-CRP) and pro-inflammatory cytokines have been suggested as sensitive markers of endothelial dysfunction. Our aim was to monitor plasma hs-CRP levels at different time-points and in different degrees of ketoacidosis severity, its association with cytokine levels and its role as a marker of severe ketoacidosis complications.
Patients And Methods: We studied in 38 newly diagnosed children with type 1 diabetes and ketoacidosis, aged 7.
Article Synopsis
- Cytokine release during Diabetic Ketoacidosis (DKA) may contribute to serious complications like cerebral or pulmonary edema by affecting capillary function.
- A study involving 38 children with newly diagnosed Type 1 Diabetes and DKA showed elevated levels of several cytokines and other markers prior to treatment, which decreased after 120 hours of management.
- In children with moderate/severe DKA, IL-10 levels dropped significantly within 6 hours, while IL-6 levels remained high initially and decreased only after 120 hours, suggesting these cytokine changes may increase the risk of acute complications.