Publications by authors named "Manoj Singh"

This paper presents a meticulously curated dataset tailored for textual sentiment analysis within the realm of technical education, falling under the domain of Natural Language Processing and Pattern Recognition. The dataset, crafted in collaboration with the All India Council for Technical Education (AICTE), encompasses over 14,000 records manually entered by representatives from technical institutes across India over the course of one year. The data, hosted on AICTE's in-house servers, has been categorized into seven distinct labels, including Appreciation, Complaint, Support, Suggestion, among others.

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  • - The text discusses the benefits of using additive flame retardants like zinc borate and alumina in epoxy formulations, emphasizing improved safety, durability, and thermal management.
  • - It highlights the use of modeling and simulation techniques to assess various flame retardants and their impact on properties like tensile strength and toughness in composites.
  • - The review emphasizes the need for thorough characterization tests, such as cone calorimetry and UL-94, to validate flame retardant properties while also addressing challenges and solutions in the current research.
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Climate change poses a significant threat to the sustainability of livestock production systems in developing countries, particularly impacting small ruminants like goats, which are highly susceptible to heat stress. This stressor not only reduces productivity but also undermines economic viability. This study aimed to delve into the molecular mechanisms underlying heat stress tolerance in goats by conducting a comprehensive transcriptome analysis of heat-tolerant (HT, n = 4) and heat-susceptible (HS, n = 6) Jamunapari goats.

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Background: The Changthangi sheep thrive at high altitudes in the cold desert regions of Ladakh, India while Muzaffarnagri sheep are well-suited to the low altitude plains of northern India. This study investigates the molecular mechanisms of pulmonary adaptation to diverse environments by analyzing gene expression profiles of lung tissues through RNA sequencing.

Methods And Results: Four biological replicates of lung tissue from each breed were utilized to generate the transcriptomic data.

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is one of the most significant therapeutical plant species that belongs to the family Liliaceae. is composed of a high amount of water, with the remainder being dry matter. The dry matter contains a lot of bioactive compounds like carbohydrates, fats, and enzymes, with various therapeutic and antimicrobial properties.

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We have established trophoblast cell lines, from parthenogenesis-derived buffalo blastocysts. The buffalo trophoblast cells were cultured continuously over 200 days and 21 passages. These cells were observed by phase-contrast microscopy for their morphology and characterized by reverse transcriptase polymerase chain reaction and immunofluorescence against trophoblast-specific markers and cytoskeletal proteins.

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  • The study investigates the relationship between skin pigmentation changes in systemic sclerosis and the severity of cutaneous sclerosis as well as internal organ involvement.
  • It found that patients with pigmentary alterations had significantly higher modified Rodnan skin scores, indicating more severe skin involvement.
  • While most patients had lung complications, those with skin pigmentation exhibited lower scores on high-resolution CT scans, suggesting a complex interaction between skin changes and organ health.
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Background: Goat milk is gaining popularity as a superior alternative to bovine milk due to its closer resemblance to human milk. Understanding the molecular processes underlying lactation is crucial for improving milk quality and production in goats. However, the genetic mechanisms governing lactation in goats, particularly in indigenous breeds like the Jakhrana, remain largely unexplored.

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The present study outlines the preparation of a ternary nanocomposite film comprising of polyaniline doped with camphor sulfonic acid (PANI), reduced graphene oxide (rGO), and graphitic carbon nitride (g-CN), and delves into its thermoelectric performance. PANI is known to possess high electrical conductivity () and poor thermal conductivity (). However, its potential for thermoelectric applications is constrained by the low value of the Seebeck coefficient ().

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Microcrystalline cellulose (MCC) is a crucial component in various industries, including pharmaceuticals, culinary, and cosmetics. The growing demand for MCC has spurred research into extraction methods. This study focused on extracting MCC from Ficus benghalensis using acid hydrolysis to convert the alpha-cellulose content of its leaves into MCC.

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The present surge in environmental consciousness has pushed for the use of biodegradable plasticizers, which are sustainable and abundant in plant resources. As a result of their biocompatibility and biodegradability, leaf plasticizers (CLP) serve as viable alternatives to chemical plasticizers. First time, the natural plasticizers from the Calotropis leaves were extracted for this study using a suitable chemical approach that was also environmentally friendly.

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Milk is a good source of nutrition but is also a source of allergenic proteins such as α-lactalbumin, β-lactoglobulin (BLG), casein, and immunoglobulins. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas technology has the potential to edit any gene, including milk allergens. Previously, CRISPR/Cas has been successfully employed in dairy cows and goats, but buffaloes remain unexplored for any milk trait.

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Begomoviruses have emerged as destructive pathogens of crops, particularly in the tropics and subtropics, causing enormous economic losses and threatening food security. Epidemics caused by begomoviruses have even spread in regions and crops that were previously free from these viruses. The most seriously affected crops include cassava; cotton; grain legumes; and cucurbitaceous, malvaceous, and solanaceous vegetables.

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Somatic cell nuclear transfer (SCNT) is a very important reproductive technology with many diverse applications, such as fast multiplication of elite animals, the production of transgenic animals and embryonic stem (ES) cells. However, low cloning efficiency, a low live birth rate and the abnormally high incidence of abnormalities in the offspring born are attributed to incomplete or aberrant nuclear reprogramming. In SCNT embryos, the aberrant expression pattern of the genes throughout embryonic development is responsible for the incomplete nuclear reprogramming.

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The current study attempts to investigate the differences in gene expression in longissimus thoracis muscles between sheep breeds acclimated to diverse environments. Changthangi sheep inhabits the cold arid plateau of Ladakh, at an altitude above 3000 m with prevalence of rarefied atmosphere. Muzzafarnagri sheep, on the other hand is found in the sub-tropical hot and humid plains at an altitude of about 250 m.

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Herbicide use may pose a risk of environmental pollution or evolution of resistant weeds. As a result, an experiment was carried out to assess the influence of different non-chemical weed management tactics (one hoeing (HH) at 12 DAS followed by (fb) one hand weeding at 30 DAS, one HH at 12 DAS fb Sesbania co-culture and its mulching, one HH at 12 DAS fb rice straw mulching @ 4t ha, one HH at 12 DAS fb rice straw mulching @ 6 t ha) on weed control, crop growth and yield, and economic returns in direct-seeded rice (DSR). Experiment was conducted during kharif season in a split-plot design and replicated thrice.

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 The objective of this study includes the NEMA (National Electrical Manufacturer Association) NU2-2018 performance evaluation of the uMIvista PET-CT (positron emission tomography-computed tomography) system.  The latest NEMA NU2-2018 guidelines have been followed for the evaluation of performance parameters of this PET-CT scanner: axial, tangential, and radial spatial resolution, sensitivity, counting losses, scatter, randomness, random and counting loss correction, image quality, time and energy resolution, image uniformity, and image registration alignment post installation of country first uMIvista PET-CT.  The measured NEMA sensitivity of the uMIvista PET scanner was 12.

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Ladakh, one of the highest inhabited regions globally, hosts the unique Changthangi goat, renowned for producing Pashmina, the world's most luxurious natural fiber. In comparison, the fiber derived from Changthangi sheep is considered next only to Pashmina. This research endeavors to compare the skin transcriptome profiles of Changthangi goats and Changthangi sheep, aiming to discern the molecular determinants behind the recognition of Changthangi goats as the source of Pashmina.

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We present a facile and versatile strategy for enabling CsPbI rods to self-assemble at an air-water interface. The CsPbI rods, which float at the air-water interface, align under the influence of the rotational flow field due to the vortex motion of a water subphase. The aligned CsPbI rods could be transferred onto various substrates without involving any sophisticated instrumentation.

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Singh MK. Hail the HACOR as a Customized Indian Weaning Score! Indian J Crit Care Med 2024;28(3):198-199.

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Background: Quantitative real-time PCR (qPCR) is a highly reliable method for validating gene expression data in molecular studies due to its sensitivity, specificity, and efficiency. To ensure accurate qPCR results, it's essential to normalize the expression data using stable reference genes.

Methods: This study aimed to identify suitable reference genes for qPCR studies in goats by evaluating 18 candidate reference genes (ACTB, BACH1, B2M, GAPDH, HMBS, HPRT1, PGK1, PPIA, PPIB, RPLP0, RPL19, RPS9, RPS15, RPS28, SDHA, TBP, UXT, and YWHAZ) in 10 different caprine tissues (heart, intestine, kidney, liver, lung, muscle, rumen, skin, spleen, and testis).

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Plasticizers are active ingredients added to the polymer to increase its workability. Since synthetic plasticizer is not ecofriendly and toxic in nature, it is a real cause for concern. On this basis, our study focuses on plasticizer extraction from plant-based resources.

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Article Synopsis
  • * Nanobiotechnology is emerging as a promising solution that utilizes nanomaterials, particularly two-dimensional nanomaterials (2D-NMs), for improved diagnosis and treatment of NDDs due to their beneficial properties like precise drug delivery and low toxicity.
  • * This review emphasizes the importance of 2D-NMs in providing innovative applications for NDDs, including biosensing, targeted drug delivery, and tissue engineering, while highlighting the lack of comprehensive studies focused specifically on these materials in the context of neurodegenerative disorders.
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  • - Recent advancements in drug delivery systems have highlighted the use of micelles made from amphiphilic block copolymers, which present benefits like biodegradability, biocompatibility, and sustained drug release, but require further enhancements for efficiency and stability.
  • - Researchers are working on optimizing the performance of these micelles by addressing challenges like toxicity and stability, while employing various strategies such as protecting hydrophobic cores and prolonging blood circulation through polyethylene oxide coatings.
  • - This article discusses the potential of nanoscale self-assembled structures for drug delivery and emphasizes the need for rigorous research and structural modifications to improve micelle efficacy in clinical applications.
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