Publications by authors named "Manoj Kakwani"

A series of novel N-(3-aryl-1,2,4-triazol-5-yl) cinnamamide derivatives were designed on basis of structural similarity to the known FAS II inhibitors. Topliss operational method was used to optimize the potency of molecules. The minimum inhibitory concentration (MIC) of all synthesized compounds was determined against Mycobacterium tuberculosis H(37)R(v) using resazurin microtitre assay (REMA) plate method.

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Article Synopsis
  • A series of cinnamide derivatives were created as potential drugs to fight tuberculosis using a method that combines elements from different chemical compounds.
  • These compounds were tested to see how effective they were at inhibiting the growth of Mycobacterium tuberculosis, showing good to moderate activity with MIC values ranging from 5-150 μM.
  • The most effective compound, labeled 1a, showed a very low MIC of 5.1 μM and worked well in combination with another antibiotic, rifampicin.
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In an attempt to identify potential new agents active against tuberculosis, 20 novel phenylacrylamide derivatives incorporating cinnamic acids and guanylhydrazones were synthesized using microwave assisted synthesis. Activity of the synthesized compounds was evaluated using resazurin microtitre plate assay (REMA) against Mycobacterium tuberculosis H37Rv. Based on empirical structure-activity relationship data it was observed that both steric and electronic parameters play major role in the activity of this series of compounds.

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