Publications by authors named "Manoj Hang Limbu"
Article Synopsis
- Chronic kidney disease (CKD) often involves proteinuria and the buildup of extracellular matrix (ECM) in the kidneys, with MMP-2 playing a key role in ECM metabolism and CKD progression.
- The study investigates how autophagy affects MMP-2 activity, particularly focusing on the role of Rab7 in this regulation and the response of kidney cells to excess albumin.
- Results show that enhancing Rab7 can reduce the harmful effects of albumin on kidney cells by regulating MMP-2 and improving cellular health, suggesting Rab7 as a potential target for kidney disease treatment.
It is already a proven fact that there exists a relationship between CLD (chronic liver disease) and kidney disease but still there is no available combined animal model of liver and kidney fibrosis on the same animal. An animal model is one of the important research tools in the field of medical science because it is important to build a model that can simulate the disease condition so that the particular disease can be studied. Therefore, the aim of this study is to build a less expensive, less time consuming, and reproducible model of hepatorenal fibrosis on rats.
View Article and Find Full Text PDFA modified approach to establish a murine model of hypoxic renal interstitial fibrosis.
Int J Clin Exp Pathol
July 2017
Article Synopsis
- The study explores modeling methods for murine hypoxic renal interstitial fibrosis, highlighting the challenges of traditional methods (5/6 nephrectomy and unilateral ureteral obstruction) and advocating for a more promising approach using cyclosporin A (CsA).
- A new method was designed to induce renal interstitial fibrosis by administering CsA and furosemide via gavage, replacing previous injection and diet methods, demonstrating successful model establishment with specific dosage over 28 days.
- Results showed significant expression of renin and hypoxia-inducible factor-1α (HIF-1α), indicating the activation of the renin-angiotensin-aldosterone system (RAAS) and the
Article Synopsis
- Gelatinases belong to the matrix metalloproteinase (MMP) family and are crucial for extracellular matrix (ECM) degradation, impacting chronic kidney disease (CKD) development.
- Their expression and activity are influenced by cell signaling pathways, hypoxia, and changes in cell membrane structure.
- Research is increasingly focused on their non-proteolytic functions and interactions with various factors like TNFs and oxidative stress, enhancing our understanding of their role in CKD.