Molecular trail for the anticancer behavior of a novel copper carbohydrazone complex in BRCA1 mutated breast cancer.

Novel chelated metal complexes were synthesized from carbohydrazones to thiocarbohydrazones using metal-based drug designing platforms and their combination effect with Pb, a naphthaquinone were analyzed for anticancer activity in breast cancer cell lines. A panel of BRCA1 wild-type and mutated breast cancer cells: MCF-7 (BRCA1 /ER ), MDA-MB-231 (BRCA1 /ERα ), HCC-1937 (BRCA1 /ERα ), HCC1937/wt BRCA1, MX1 (BRCA1 /ERα ), and MDA-MB-436 (BRCA1 /ERα ) were screened for anti-cancer activity. Cu (HL)(HSO ) · H O]SO  · 6 H O (CS2) is the most potent anticancer agent among the copper carbohydrazone and thiocarbohydrazone complexes analyzed in this study.