Publications by authors named "Manoharan Shunmugam"
Article Synopsis
- The paper looks at how inherited retinal diseases (IRD) are diagnosed and treated in the Asia-Pacific region.
- They surveyed 36 centers about their practices, including how they collect patient information and provide help for low vision.
- The results showed there are important gaps, like many centers not having a database for patients, not enough genetic counselors, and a need for better support for low-vision rehabilitation.
Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases.
Asia Pac J Ophthalmol (Phila)
February 2024
Article Synopsis
- The Asia-Pacific region, housing about 60% of the world's population, lacks extensive knowledge about hereditary eye diseases, necessitating a regional collaboration to enhance precision medicine for affected patients.
- The Asia-Pacific Inherited Eye Disease (APIED) network, consisting of 55 members from 35 centers across 12 countries, aims to address these gaps in understanding inherited retinal diseases (IRDs) by bringing together experts in the field.
- The network's goals include improving genetic diagnosis of IRDs, standardizing phenotyping practices, and creating high-quality patient registries to support care and research in both regional and international contexts.*
Purpose: Dramatically improved health care in recent years has increased the life expectancy of patients with sickle cell disease (SCD) as well as the prognosis for its ocular complications. We sought to identify risk factors for visual impairment in patients with SCD in London 4 decades after Goldberg's seminal studies.
Methods: Patients 16 years and older with SCD (genotypes HbSS, HbSC, HbSβ-thalassemia) attending hematology and ophthalmology services were offered ocular examination.
Aim: To evaluate the functional outcome after removal of silicone oil (ROSO) in patients undergoing retinectomy for complex retinal detachment.
Methods: We performed a retrospective case note review of patients who underwent ROSO after retinectomy for complex retinal detachment. Patients with less than 6mo follow up and recurrent retinal detachment following ROSO were excluded.
Purpose: To investigate spectral domain optical coherence tomography findings in long-term silicone oil-related visual loss.
Methods: Four symptomatic patients were reviewed 4 years to 9 years after vitrectomy with silicone oil tamponade for macula-on retinal detachment. Three lost vision with oil in situ, with one at the time of oil removal.
Objective: The pattern of retinal features in patients with retinal detachment caused by retinal dialyses is poorly described. The association with trauma has also been inconsistently reported. The authors aim to analyze patient and retinal characteristics in such cases and identify the proportion where trauma is likely causative mechanism.
View Article and Find Full Text PDFPurpose: To determine features of rhegmatogenous retinal detachment predictive of anatomical success with surgical procedure.
Methods: All patients undergoing surgery at a tertiary referral practice had contemporaneous data collection in an electronic database. Overall, 847 eyes from 847 patients undergoing surgical procedure for rhegmatogenous retinal detachment were included in this study.
Purpose: To identify which presenting features of rhegmatogenous retinal detachment (RRD) suggest the presence of multiple retinal breaks and to ascertain relevant patterns in retinal break location.
Design: Observational single-center case series.
Methods: We collected data from 851 eyes undergoing surgery for RRD between January 2001 and September 2011.
A giant retinal tear (GRT) is a full-thickness neurosensory retinal break that extends circumferentially around the retina for three or more clock hours in the presence of a posteriorly detached vitreous. Its incidence in large population-based studies has been estimated as 1.5% of rhegmatogenous retinal detachments, with a significant male preponderance, and bilaterality in 12.
View Article and Find Full Text PDFBackground: Lack of clinical tests to quantify spatial components of distortion in patients with full thickness macular holes (FTMH) and epiretinal membranes (ERM).
Aim: To develop a test for subjective evaluation of visual distortion in the central visual field around fixation in patients with unilateral FTMH or ERM.
Settings And Design: Prospective case-control study carried out at tertiary referral center.
Aims: To investigate the incidence of macula displacement and symptoms of distortion following rhegmatogenous retinal detachment (RRD) repair, quantify the displacement where seen and further characterise the nature of the displacement.
Methods: Consecutive patients undergoing primary RRD repair were assessed postoperatively with fundus autofluorescence and optical coherence tomography imaging, and the extent of macula displacement quantified using a novel means. Findings were examined for correlations with symptoms and pre-operative features.
Purpose: To report an orbital cyst underlying a chorioretinal coloboma in an otherwise normal eye, detected by spectral domain optical coherence tomography imaging. To the authors' knowledge, this is the first case of a chorioretinal colobomatous cyst in the normal eye to be reported.
Methods: A descriptive case report of a patient with a chorioretinal coloboma with an underlying orbital cyst.
Toxic anterior segment syndrome (TASS), though rare, has been well documented following anterior segment surgery but not following vitrectomy (Monson et al., J Cataract Refract Surg 18:184-189, 1992). It typically presents within 24 h of uncomplicated cataract surgery with minimal or no pain and intense anterior segment inflammation (Monson et al.
View Article and Find Full Text PDFAir-gas exchange reevaluated: clinically important results of a computer simulation.
Invest Ophthalmol Vis Sci
October 2011
Purpose: The primary aim of this study was to evaluate the efficiency of air-gas exchange techniques and the factors that influence the final concentration of an intraocular gas tamponade. Parameters were varied to find the optimum method of performing an air-gas exchange in ideal circumstances.
Methods: A computer model of the eye was designed using 3D software with fluid flow analysis capabilities.
Wegener's granulomatosis can involve the orbit and sometimes the optic nerve. This usually occurs as a result of contiguous spread from affected sinuses or extraocular muscles, or from a vasculitic posterior optic neuropathy. However, we present an unusual case of isolated orbital apex infiltrative disease in a patient with known Wegener's granulomatosis.
View Article and Find Full Text PDFPurpose: To determine the effect of cataract extraction on the glaucoma progression index (GPI) in glaucoma patients with coexisting cataract.
Patients And Methods: This is a retrospective noncomparative study. Consecutive eligible patients with glaucoma who underwent phacoemulsification alone or in combination with augmented trabeculectomy were included.
Purpose: Scanning laser polarimetry (SLP) has been proposed as a useful diagnostic test for glaucoma. This study was conducted to evaluate the quality of reporting of published studies using the SLP for diagnosing glaucoma.
Methods: A validated Medline and hand search of English-language articles reporting on measures of diagnostic accuracy of the SLP for glaucoma was performed.
The quality of reporting of diagnostic accuracy studies in glaucoma using the Heidelberg retina tomograph.
Invest Ophthalmol Vis Sci
June 2006
Purpose: Scanning laser tomography with the Heidelberg retina tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany) has been proposed as a useful diagnostic test for glaucoma. This study was conducted to evaluate the quality of reporting of published studies using the HRT for diagnosing glaucoma.
Methods: A validated Medline and hand search of English-language articles reporting on measures of diagnostic accuracy of the HRT for glaucoma was performed.