At-home wearables and machine learning capture motor impairment and progression in adult ataxias.

A significant barrier to developing disease-modifying therapies for spinocerebellar ataxias (SCAs) and multiple system atrophy of the cerebellar type (MSA-C) is the scarcity of tools to sensitively measure disease progression in clinical trials. Wearable sensors worn continuously during natural behavior at home have the potential to produce ecologically valid and precise measures of motor function by leveraging frequent and numerous high-resolution samples of behavior. Here we test whether movement-building block characteristics (i.

Health-Seeking Behavior and Economic Burden of Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.

Background Type 2 diabetes mellitus (T2DM) is a major public health concern, affecting millions worldwide and placing a significant burden. This study aimed to assess the health-seeking behaviors and the economic burden of T2DM patients in Jaipur, Rajasthan. Methodology This cross-sectional observational study was conducted from January 2019 to June 2020 at the Community Health Centre (CHC) in Jaipur, India.

Design of a stand-alone hybrid dispersed generation network unified by passivity-based control.

In this article, we propose a model for a stand-alone hybrid distributed generation system. In this model, the input sources are distributed DC sources like solar panels or batteries. The idea behind this network framework is to introduce a hybrid DC/AC network, feasible for small and remotely located areas with stand-alone DC grids, in the vicinity of larger towns requiring a functional AC connection.

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis.

Inhibitors of the transforming growth factor-β (TGF-β) pathway are potentially promising antifibrotic therapies, but nonselective simultaneous inhibition of all three TGF-β homologs has safety liabilities. TGF-β1 is noncovalently bound to a latency-associated peptide that is, in turn, covalently bound to different presenting molecules within large latent complexes. The latent TGF-β-binding proteins (LTBPs) present TGF-β1 in the extracellular matrix, and TGF-β1 is presented on immune cells by two transmembrane proteins, glycoprotein A repetitions predominant (GARP) and leucine-rich repeat protein 33 (LRRC33).

Comparative evaluation of intranasal dexmedetomidine, intranasal midazolam, and nitrous oxide for conscious sedation of anxious children undergoing dental treatment: A randomized cross-over trial.

Background: Pharmacological methods, specifically sedatives, have gained popularity in managing the behavior of children during dental appointments.

Aim: The aim of this study was to compare 1 m/kg intranasal dexmedetomidine, 0.3 mg/kg intranasal midazolam, and nitrous oxide in evaluating the level of sedation, behavior of the child, onset of sedation, physiologic signs, and adverse effects.

Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.

Selective inhibition of the RGD (Arg-Gly-Asp) integrin αvβ1 has been recently identified as an attractive therapeutic approach for the treatment of liver fibrosis given its function, target expression, and safety profile. Our identification of a non-RGD small molecule lead followed by focused, systematic changes to the core structure utilizing a crystal structure, modeling, and a tractable synthetic approach resulted in the identification of a potent small molecule exhibiting a remarkable affinity for αvβ1 relative to several other integrin isoforms measured. Azabenzimidazolone demonstrated antifibrotic efficacy in an rat liver fibrosis model and represents a tool compound capable of further exploring the biological consequences of selective αvβ1 inhibition.

Endovascular Therapy in Large Core Ischemic Strokes: Real-World Indian Experience.

Background: Large core acute ischemic strokes have predominantly been excluded from endovascular therapy (EVT) studies due to perceived higher risks of hemorrhage and poorer functional outcomes. However, recent randomized controlled trials (RCTs) indicate that EVT for large vessel occlusion (LVO) strokes improves functional outcomes compared to medical management alone, despite higher hemorrhagic transformation rates, with no corresponding increase in symptomatic intracerebral hemorrhage (sICH) rates. The real-world outcomes of this intervention in Indian patients remain underexplored.

Endovascular Treatment for Cerebral Venous Sinus Thrombosis: Comparison among Different Endovascular Procedures.

Background: Cerebral venous sinus thrombosis (CVST) is a rare, treatable cause of stroke. Even though CVST has an established medical treatment, 15% of patients remain refractory to treatment. These patients may be candidates for endovascular treatment (EVT), yet the selection of patients remains a challenge.

The altered volume of striatum: A neuroimaging marker of treatment in first-episode and drug-naïve schizophrenia.

Although schizophrenia patients exhibit structural abnormalities in the striatum, it remains largely unknown for the role of the striatum subregions in the treatment response of antipsychotic drugs. The purpose of this study was to investigate the associations between the striatal subregions and improved clinical symptoms in first-episode drug-naïve (FEDN) schizophrenia. Forty-two FEDN schizophrenia patients and 29 healthy controls (HCs) were recruited.

Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib.

Camonsertib is a novel ATR kinase inhibitor in clinical development for advanced cancers targeting sensitizing mutations. This article describes the identification and biosynthesis of an N-glucuronide metabolite of camonsertib. This metabolite was first observed in human hepatocyte incubations and was subsequently isolated to determine the structure, evaluate its stability as part of bioanalytical method development and for use as a standard for estimating its concentration in Phase I samples.

Prevalence of Plastic Usage and the Factors Associated With It Among Adults in Perambalur District of South India: A Cross-Sectional Study.

Background People extensively use and dispose of plastic products because of their durability, affordability, and lightweight. The excessive production and consumption of plastics has led to pollution that has negative effects on both society and the environment. Nearly all Indian states and union territories have prohibited the usage of plastic bags, with Tamil Nadu being the fourth state in the country to implement such a prohibition.

Assessment of Pain During Pediatric Dental Treatment Using Different Sedative Agents: A Crossover Trial.

Background Behavioral management techniques are employed for children who are fearful and uncooperative. Pharmacologic sedation and anesthesia are frequently utilized to manage pain and anxiety in pediatric dental patients. Aim  To evaluate the intraoperative and postoperative pain levels during dental treatment of children sedated with 1.

The Relationship Between Cigarette Dependence and Cessation Methods: Implications for Smoking Cessation Among People With HIV.

Objective: These analyses investigate how dependence may be related to cessation method choice and how this relationship may vary by subpopulation among people with HIV (PWH) who smoke cigarettes.

Method: PWH who smoke ( = 71) were recruited from clinics in Boston, MA. The Fagerström Test for Nicotine Dependence (FTND) and Smoking History Questionnaire (SHQ) were completed to assess for cigarette dependence, past-week cigarettes per day (CPD), and past cessation method use.

Assessment of Microbial Contamination of a Toothbrush Head with and without a Protective Cover: An Study.

Introduction: The oral cavity is colonized by various groups of microorganisms. Toothbrushing is a common method of maintaining oral hygiene and, upon regular use, can become heavily contaminated with microorganisms. To avoid contamination of the toothbrush with microorganisms from the external environment, toothbrushes can be protected by a protective cap, the significance of which is unknown.

Exome sequencing and microarray identified a novel large exonic deletion in gene in an ultra-rare case with recessive CMS type 7.

Congenital myasthenic syndromes (CMSs) are a diverse group of diseases that have an underlying defect in transmission of signals from nerve cells to muscles that lead to muscular weakness. A 13-year-old male child born of consanguineous parents with profound motor developmental delay and normal cognition was referred to us. The younger male sibling aged 9 months was similarly affected.

Chemically Functionalized Gold Nanosphere-Blended Nematic Liquid Crystals for Photonic Applications.

A demand for functional materials that are capable of tailoring light-emissive properties has apparently been rising nowadays substantially for their utilization in organic optoelectronic devices. Motivated by such promising characteristics, we present highly emissive as well as aggregation-induced emission (AIE) electroluminescent composite systems composed of a nematic liquid crystals (NLC) blended with polyethylene-functionalized gold nanospheres (GNSs). The major findings of this study include superior electro-optical properties such as threshold voltage reduction by around 24%.

Field-programmable encoding for address-event representation.

In conventional frame-based image sensors, every pixel records brightness information and sends this information to a receiver serially in a scanning fashion. This full-frame readout approach suffers from high bandwidth requirements and increased power consumption with the increasing size of the pixel array. Event-based image sensors are gaining popularity for reducing the bandwidth and power requirements by sending only meaningful data in an event-driven approach with the help of address-event representation (AER) communication protocol.

Implementation of a Hardware-Assisted Bluetooth-Based COVID-19 Tracking Device in a High School: Mixed Methods Study.

Background: Contact tracing is a vital public health tool used to prevent the spread of infectious diseases. However, traditional interview-format contact tracing (TCT) is labor-intensive and time-consuming and may be unsustainable for large-scale pandemics such as COVID-19.

Objective: In this study, we aimed to address the limitations of TCT.

Molecular docking study on europium nanoparticles and mussel adhesive protein for effective detection of latent fingerprints.

Reflecting on the difficulty of finding the evidence of latent fingerprints on wet and rough surfaces, scientists need to visualise those fingermarks without any background interference and stable adhesion of visualising material over the fingermark residues. To stabilize the interaction with the fingermarks, the synthesized nanoparticles were conjugated with a highly adhesive biopolymer, Mussel Adhesive Protein (MAP) which can effectively interact with fingerprint deposits. Rare earth metal, europium oxide and nanoparticles were used as a visualisation material to get high contrast and reduced background interference-based fingerprints.

A systemic review on liquid crystals, nanoformulations and its application for detection and treatment of SARS - CoV- 2 (COVID - 19).

The COVID-19 is a pandemic caused by the SARS-CoV-2 virus, has instigated major health problems and prompted WHO to proclaim a worldwide medical emergency. The knowledge of SARS-CoV-2 fundamental structure, aetiology, its entrance mechanism, membrane hijacking and immune response against the virus, are important parameters to develop effective vaccines and medicines. Liquid crystals integrated nano-techniques and various nanoformulations were applied to tackle the severity of the virus.

Pilot Evaluations of Two Bluetooth Contact Tracing Approaches on a University Campus: Mixed Methods Study.

Background: Many have proposed the use of Bluetooth technology to help scale up contact tracing for COVID-19. However, much remains unknown about the accuracy of this technology in real-world settings, the attitudes of potential users, and the differences between delivery formats (mobile app vs carriable or wearable devices).

Objective: We pilot tested 2 separate Bluetooth contact tracing technologies on a university campus to evaluate their sensitivity and specificity, and to learn from the experiences of the participants.

Superior improvement in dynamic response of liquid crystal lens using organic and inorganic nanocomposite.

In this study, the response time of a 4 mm-aperture hole-patterned liquid crystal (HLC) lens has been significantly improved with doping of N-benzyl-2-methyl-4-nitroaniline (BNA) and rutile titanium dioxide nanoparticle (TiO NP) nanocomposite. The proposed HLC lens provides the focus and defocus times that are 8.5× and 14× faster than the pristine HLC lens, respectively.

Myoclonus-Ataxia Syndrome Associated with COVID-19.

Neurological manifestations of coronavirus disease (COVID-19) have increasingly been reported since the onset of the pandemic. Herein, we report a relatively new presentation. A patient in the convalescence period following a febrile illness with lower respiratory tract infection (fever, myalgia, nonproductive cough) presented with generalized disabling myoclonus, which is phenotypically suggestive of brainstem origin, along with additional truncal cerebellar ataxia.

The effect of fennel seeds on pH of saliva - A clinical study.

Context: Saliva is an oral fluid that gives a protective effect against dental caries. Chewing of fennel seeds after food is a common culture in the Indian Sub-continent. A review of previous studies on fennel seeds showed that some of them have an anti-microbial efficacy, but there are no extensive data available on the effect of chewing fennel seeds on the pH of saliva.

In vitro cytochrome P450- and transporter-mediated drug interaction potential of 6β-hydroxy-21-desacetyl deflazacort-A major human metabolite of deflazacort.

6β-Hydroxy-21-desacetyl deflazacort (6β-OH-21-desDFZ) is a major circulating but not biologically active metabolite of deflazacort (DFZ). In vitro studies were performed to evaluate cytochrome P450 (CYP)- and transporter-mediated drug interaction potentials of 6β-OH-21-desDFZ. Up to 50 µM, the highest soluble concentration in the test system, 6β-OH-21-desDFZ weakly inhibited (IC  > 50 µM) the enzyme activity of CYPs 1A2, 2B6, 2C8, 2C9, and 2D6, while moderately inhibiting CYP2C19 and CYP3A4 with IC values of approximately 50 and 35 μM, respectively.