Increased prevalence of colorectal adenomas in women with breast cancer.

Background: The frequency of colorectal adenomas and carcinomas was investigated in a large cohort of women with breast cancer in comparison with matched controls, since data on the occurrence of second tumors in women with breast cancer is controversial.

Design: In a cohort study, 188 consecutive women (median age 57 years) with primary breast cancer and 376 age-matched women who served as controls were examined by total colonoscopy. Breast cancer patients and controls were compared for the frequency of colorectal adenomas and carcinomas.

[Successful conservative management in two patients with a tracheobronchial rupture].

A 30-year-old woman with blunt chest trauma after falling from a horse appeared to have a haematothorax. Bronchoscopy showed a bronchial rupture of the posterior segment of the right upper lobe. As her condition was stable, a policy of expectant management was instigated.

[Diagnosis and treatment of bronchiectasis].

Patients with bronchiectasis usually have chronic pulmonary infection with secondary obstructive airway disease. This disease has to be distinguished from chronic obstructive pulmonary disease (COPD). The diagnosis is established with the help of high resolution CT scan of the thorax.

[Diagnostic image (123). A man on oxygen therapy and facial burns. First and second degree burns in the face after a flame during nasal oxygen administration].

A 66-year-old man was hospitalised because of pneumonia and chronic obstructive pulmonary disease. He suffered from facial burns when he tested a cigarette lighter whilst on oxygen therapy by nasal prongs.

[Signs of miliary tuberculosis: which diagnostic tests and when to treat?].

Three patients, men aged 21, 57 and 53 years, presented with variable non-specific symptoms such as general malaise, weight loss, elevated temperature, abdominal pain, cough, pulmonary crepitations and elevated liver enzymes. Diffuse fine nodular infiltration was seen on chest radiography in the last two cases. The first patient refused to be tentatively treated with tuberculostatics and died.

Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2. Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients.

The aim of the present study was to perform a proof of principle study with a new colistin dry powder inhalation system in six healthy volunteers and five patients with cystic fibrosis. All subjects were asked to inhale 25 mg colistin sulfate dry powder. The patients were also asked to nebulize 160 mg colistin sulfomethate as a solution.

Can tobramycin inhalation be improved with a jet nebulizer?

Data on the pharmacokinetics of antibiotics after inhalation are limited. The aim of this pilot study was to assess the pharmacokinetics of tobramycin under optimalized and standardized aerosol circumstances and, furthermore, to be able to consider possible treatment of exacerbations with inhalation therapy. Six patients were studied after inhalation of 600 mg tobramycin.

[Cystic fibrosis: special value of treatment at a center].

A woman aged 30 and a man aged 40, both with a bad general condition due to cystic fibrosis, showed a clear clinical improvement after they were treated in a cystic fibrosis centre, while in a young adult male patient the diagnosis of cystic fibrosis could be rejected. In the Netherlands there are approximately 1000 patients with cystic fibrosis. As a consequence most doctors have hardly any experience of the treatment of such patients.

An increasing dose of omeprazole combined with amoxycillin cures Helicobacter pylori infection more effectively.

Background: The combination of omeprazole and amoxycillin has demonstrated effectiveness with very few side-effects in the treatment of H. pylori infection, however cure rates have varied widely. The present study addresses the question as to the extent to which the cure rate of H.

Quality of life in patients with cystic fibrosis.

The majority of patients with cystic fibrosis (CF) will grow into adulthood. Despite this improvement in survival, the disease is progressive, especially with respect to the decline in pulmonary function, which in turn may have an impact on a patient's quality of life. In this study we evaluated the quality of life in CF adults and examined the relationship between quality of life and pulmonary function, exercise capacity, and dyspnea.

Relationship between dyspnoea, pulmonary function and exercise capacity in patients with cystic fibrosis.

The median age of survival in patients with cystic fibrosis (CF) has improved considerably. Despite this improvement, deterioration of pulmonary function and decrease in exercise capacity are still the main problems for many patients. Although dyspnoea is a common complaint in CF patients, relatively little regard has been paid to this symptom.

Helicobacter pylori reinfection is rare in peptic ulcer patients cured by antimicrobial therapy.

Background: Cure of H. pylori infection in peptic ulcer patients significantly reduces the risk of ulcer recurrence. Since data on the rate of H.

Severity of Helicobacter pylori gastritis predicts duodenal ulcer recurrence.

Background: Helicobacter pylori gastritis is suggested to be the underlying condition leading to duodenal ulcer disease. The aim of the study was to investigate the relationship between chronic active H. pylori gastritis and the risk of duodenal ulcer (DU) recurrence.

Serodiagnosis and monitoring of Aspergillus infections after lung transplantation.

Objective: To determine whether quantification of specific antifungal antibody responses in serum can provide supplemental information for the diagnosis of Aspergillus fumigatus infections and the monitoring of antifungal treatment in patients after lung transplantation.

Design: Retrospective study.

Setting: Center for lung transplantation, University Hospital Groningen, the Netherlands.

[Results of 75 lung transplantations performed in Groningen in 1990-1995. Lung Transplantation Group Groningen].

Objective: To describe the development of the lung transplantation programme in Groningen, and the results of single and bilateral lung transplantations in the first 75 consecutive patients, up to December 1995.

Design: Retrospective.

Setting: Academic Hospital Groningen, the Netherlands.

Renal hemodynamics after lung transplantation. A prospective study.

Renal function impairment is common after solid organ transplantation, due to the nephrotoxicity of cyclosporine. Moreover, in patients with severe respiratory failure, renal function is often impaired. This renal function impairment may predispose patients to further renal function impairment after lung transplantation.

Cure of gastric ulcer disease after cure of Helicobacter pylori infection--German Gastric Ulcer Study.

Background: Helicobacter pylori infection is associated with gastric ulcer disease in about 75% of cases.

Objective: The aim of this study was to determine whether H. pylori eradication reduces gastric ulcer relapse rates.

Three hundred patients referred for lung transplantation. Experiences of the Dutch Lung Transplantation Program. Groningen Lung Transplantation Group.

In November 1990, a lung transplantation program began at the University Hospital in Groningen, the Netherlands. As of April 1994, 300 patients were referred for lung transplantation and we investigated the decisions that have been made concerning these referrals up to January 1, 1995. The patients were evaluated according to a stepwise procedure.

Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection.

Background: Chronic Helicobacter pylori-associated gastritis is now widely accepted as one of the most important pathogenic factors in duodenal ulcer disease. However, little is known about for how long patients remain free of duodenal ulcer relapses after H. pylori infection has been cured.

Spontaneous pneumopericardium related to active cytomegaloviral infection in a lung transplant recipient. The Groningen Lung Transplantation Group.

Spontaneous pneumopericardium occurred in a patient almost 4 weeks after bilateral lung transplantation for cystic fibrosis. The patient had no specific complaints and was in stable haemodynamic condition. We suggest that this pneumopericardium was related to a concomitant active cytomegalovirus (CMV) infection.

Liposomal amphotericin B in three lung transplant recipients. The Groningen Lung Transplantation Group.

Background: Opportunistic fungal infections are an important cause of morbidity and mortality in solid organ transplant recipients. Conventional therapy with amphotericin B is often restricted by toxicity. However, side effects and toxicity of liposomal amphotericin B are reported to be limited.

Lung transplantation in patients with cystic fibrosis. The Groningen Lung Transplantation Group.

Worldwide more than 600 heart-lung or lung transplantations have been performed in patients with cystic fibrosis and end-stage respiratory disease. At the University Hospital in Groningen 10 patients with cystic fibrosis underwent bilateral sequential lung transplantation until April 1994. The 1-year survival was 76%, which is similar to that of lung transplant recipients with other diseases.