Publications by authors named "Mann-Tin Lui"
miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFβRII expression was found in metastatic HNSCC samples.
View Article and Find Full Text PDFObjectives: MicroRNAs (miRNAs) are endogenous small non-coding RNAs that negatively regular target gene expression by RNA interference. The processing of the pre-miRNA hairpin generates a miRNA duplex, which consists of a miRNA (guide strand) and a miRNA(*) (passenger strand). miR-31 is an oncogenic miRNA and is up-regulated in oral squamous cell carcinoma (OSCC).
View Article and Find Full Text PDFArticle Synopsis
- Oral squamous cell carcinoma (OSCC) is strongly linked to areca (betel) chewing among Asians, with several hundred million at risk due to this habit.
- Significant genetic changes, particularly in the CCND1 and CTTN genes located on chromosome 11q13, are observed in nearly half of the OSCC cases studied, indicating their role in cancer development.
- The study suggests a potential for early detection of OSCC using non-invasive brushing methods combined with quantitative PCR analysis to identify gene amplifications in high-risk populations.