Asian Study of Cerebral Venous Thrombosis.

Background/objective: Most of the studies and registries related to cerebral venous thrombosis (CVT) are reported from European countries and the United States. The objective of the present study is to identify risk factors, presentation, and outcome of CVT in Asian patients.

Methods: Asian CVT registry is a prospective multinational observational study that included patients (aged > 16 years) with symptomatic CVT.

Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.

The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance. Swiss albino mice were kindled by a subconvulsive dose of pentylenetetrazole (PTZ, 30 mg/kg, i.p.

Ptosis and diplopia as initial manifestation of Guillain-Barré syndrome.

In this case report a 58-year-old Guillain-Barre syndrome patient in India presents with ptosis and diplopia. Cranial nerve examination revealed bilateral restricted abduction and ptosis as shown in the associated video clip.

Acute onset distal symmetrical vasculitic polyneuropathy associated with acute hepatitis B.

Hepatitis B can have varied extrahepatic manifestations involving the skin, renal, haematological and nervous systems. Neurological manifestations in hepatitis B may take the form of Guillain-Barré syndrome and secondary systemic vasculitis-related mononeuritis multiplex. The clinical course of hepatitis B-related, vasculitis-related neuropathy is usually subacute to chronic and clinical evolution is relatively benign.

Posterior circulation ischemic stroke-clinical characteristics, risk factors, and subtypes in a north Indian population: a prospective study.

Background And Purpose: Posterior circulation stroke accounts for approximately 20% of all strokes with varied clinical presentation, which differ from strokes in anterior circulation, with reference to etiology, clinical features, and prognosis. Short penetrating and circumferential branches in the posterior circulation supply the brain stem, thalamus, cerebellum, occipital, and medial temporal lobes.

Materials And Methods: We prospectively analyzed 80 participants of posterior circulation ischemic stroke from a registry of 944 participants attending a tertiary care referral university hospital.

Concomitant appearance of pisa syndrome and striatal hand in Parkinson's disease.

Pisa syndrome is (PS) usually seen in patients receiving antipsychotic drugs and characterised by lateral flexion of trunk and axial dystonia. It is believed that antipsychotic drugs lead to dopamine blockage causing PS. We describe a Parkinson's disease patient who was doing well with levodopa/carbidopa for 3 years and developed lateral flexion of trunk.

Nonmotor symptom complex of Parkinson's disease--an under-recognized entity.

Parkinson's disease (PD) is the second most common neurodegenerative disorder, after Alzheimer's disease. The cardinal clinical features of PD include asymmetric onset of bradykinesia, rigidity, and resting tremor. Most patients of idiopathic PD present with one or more of the cardinal motor features.