Publications by authors named "Manlio-Joaquin Graniel-Sabido"
Biomed Chromatogr
April 2019
Article Synopsis
- Several methods for measuring tamoxifen and its metabolites exist, mainly using complex and costly liquid chromatography tandem-mass spectrometry (LC-MS/MS), which can be time-consuming and affected by matrix ionization issues.
- A new, validated method has been developed using high-performance liquid chromatography with fluorescence detection, allowing rapid and efficient quantification of tamoxifen and its active metabolites in just 16 minutes, plus a short re-equilibration time.
- This new approach is accurate, precise, requires minimal plasma sample, and is particularly beneficial for use in clinical studies and healthcare settings, especially in developing countries.
