Current status of fertility preservation procedures in gynecologic oncology: from a Chinese perspective.

Background: The "Healthy China" initiative, along with advancements in technology for cancer diagnosis and treatment, has significantly enhanced outcomes for patients with gynecologic tumors. The trends of late marriage and delayed childbirth have led to an increasing number of women diagnosed with gynecologic cancers who are seeking fertility preservation in China. This issue is critical yet often overlooked in clinical practice.

Time-Lapse Acquisition of Both Freely Secreted Proteome and Exosome Encapsulated Proteome in Live Organoids' Microenvironment.

Proteomic communications in neighboring microenvironments during early organ development is a dynamic process that continuously reshapes human embryonic stem cells (hESCs) developmental fate. Such dynamic proteomic alteration in the microenvironment consists of both freely secreted proteome and exosome-encapsulated proteome. Simultaneous monitoring of the time-lapse shift of both proteomes with live organoids remains technically challenging.

Realizing Outstanding Energy Storage Performance in KBT-Based Lead-Free Ceramics via Suppressing Space Charge Accumulation.

The great potential of KBiTiO (KBT) for dielectric energy storage ceramics is impeded by its low dielectric breakdown strength, thereby limiting its utilization of high polarization. This study develops a novel composition, 0.83KBT-0.

MiR-136-5p in cancer: Roles, mechanisms, and chemotherapy resistance.

MicroRNAs (miRNAs) have emerged as important regulators of gene expression, and the deregulation of their activity has been linked to the onset and progression of a variety of human malignancies. Among these miRNAs, miR-136-5p has attracted significant attention due to its diverse roles in cancer biology. Mostly, miR-136-5p is downregulated in malignancies.

Construction of continuous flow catalytic reactor-HPLC system with ultrahigh catalytic activity using 2D nanoflower MOF-derived CuO/Cu/PDA/CF catalyst.

Currently, metal-organic frameworks (MOFs) derived materials have been widely concerned for the reduction of 4-nitrophenol (4-NP). However, complex recovery of powder catalysts and low utilization ratio of active sites make their application challenging. Herein, a novel CuO/Cu/PDA/CF catalyst has been developed for the rapid reduction of 4-NP to 4-aminophenol (4-AP).

Tunable Fluorine-Functionalized Scholl-Coupled Microporous Polymer for the Selective Adsorption and Ultrasensitive Analysis of Environmental Liquid-Crystal Monomers.

Liquid-crystal monomers (LCMs), especially fluorinated biphenyls and analogues (FBAs), are identified to be an emerging generation of persistent organic pollutants. However, there is a dearth of information about their occurrence and distribution in environmental water and lacustrine soil samples. Herein, a series of fluorine-functionalized Scholl-coupled microporous polymers (FSMP-, X = 1-3) were designed and synthesized for the highly efficient and selective enrichment of FABs.

Research advances in endometriosis-related signaling pathways: A review.

Endometriosis (EM) is characterized by the existence of endometrial mucosa outside the uterine cavity, which causesinfertility, persistent aches, and a decline in women's quality of life. Both hormone therapies and nonhormone therapies, such as NSAIDs, are ineffective, generic categories of EM drugs. Endometriosis is a benign gynecological condition, yet it shares a number of features with cancer cells, including immune evasion, survival, adhesion, invasion, and angiogenesis.

Micro-matrix cartridge extraction followed by online micro-solid phase extraction based on polystyrene@hydroxypropyl-β-cyclodextrin nanofibers for selective determination of fipronil and its metabolites in soil.

Micro-matrix cartridge extraction coupled on-line to micro-solid phase extraction-high performance liquid chromatography-mass spectrometry (μ-MCE-online-μ-SPE-HPLC-MS) is presented. Micro-matrix cartridge extraction (μ-MCE) was applied to highly efficient desorption of adsorbed pesticides from contaminated soil with favorable extraction efficiency (100%). Novel polystyrene@hydroxypropyl-β-cyclodextrin (PS@HPCD) electrospun nanofibers with 3D network structure were prepared to selectively capture fipronil and its metabolites.

A recessive gene Cmpmr2F confers powdery mildew resistance in melon (Cucumis melo L.).

Identified a recessive gene (Cmpmr2F) associated with resistance to infection by the powdery mildew causing agent Podosphaera xanthii race 2F. Powdery mildew (PM) is one of the most destructive fungal diseases of melon, which significantly reduces the crop yield and quality. Multiple studies are being performed for in-depth genetic understandings of PM-susceptibility or -resistance mechanisms in melon plants, but the holistic knowledge of the precise genetic basis of PM-resistance is unexplored.

Designing Hierarchically Porous Single Atoms of Fe-N Catalytic Sites with High Oxidase-like Activity for Sensitive Detection of Organophosphorus Pesticides.

Recently, single-atom catalysts (SACs) have been used to construct biosensors for the determination of organophosphorus pesticides (OPs). However, most nanozymes including SACs are peroxidase-like enzymes and require highly toxic and unstable hydrogen peroxide (HO) as a co-reactant to generate reactive oxygen species. Inspired by the heme site of cytochrome oxidases (Cos), the construction of Fe-N-coordinated SACs by introducing axial N ligands is expected to bind O to generate active metal-oxygen intermediates.

Construction of plasmonic Bi/Bismuth oxycarbonate/Zinc bismuth oxide ternary heterojunction for enhanced charge carrier separation and photocatalytic performances.

In this work, a novel plasmonic ternary Bi/Bismuth oxycarbonate/Zinc bismuth oxide (Bi-BiOCO-ZnBiO) is synthesized synergistically by a one-step hydrothermal method. The results show that the metallic Bi spheres and ZnBiO nanoparticles are uniformly distributed on the surface of flower-like BiOCO layer. Compared with the bare ZnBiO and Bi-BiOCO, the ternary Bi-BiOCO-ZnBiO heterojunction displays a significantly improved solar energy harvesting efficiency and enhanced photocatalytic degradation activity for environmental organic pollutants.

BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis.

Lung adenocarcinoma (LUAD) is one of the most common causes of cancer death in men. BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) has been reported to contribute to the initiation and development of several cancers. Here, we aimed to explore the potential role of BUB1B in LUAD.

Polymer Functionalized Nanoparticles in Blue Phase LC: Effect of Particle Shape.

Ethylene oxide oligomers and polymers, free and tethered to gold nanoparticles, were dispersed in blue phase liquid crystals (BPLC). Gold nanospheres (AuNPs) and nanorods (AuNRs) were functionalized with thiolated ethylene oxide ligands with molecular weights ranging from 200 to 5000 g/mol. The BPLC mixture (ΔT ~6 °C) was based on the mesogenic acid heterodimers, n-hexylbenzoic acid (6BA) and n--butylcyclohexylcarboxylic acid (4-BCHA) with the chiral dopant (R)-2-octyl 4-[4-(hexyloxy)benzoyloxy]benzoate.

Circ-CCS is identified as a cancer-promoting circRNA in lung cancer partly by regulating the miR-383/E2F7 axis.

Background: Increasing biomolecules have been found to be involved in the lung cancer development. This study will perform the function and mechanism analyses of a novel circular RNA copper chaperone for superoxide dismutase (circ-CCS) in lung cancer.

Methods: Circ-CCS, microRNA-383 (miR-383) and E2F transcription factor 7 (E2F7) were quantified by quantitative real-time polymerase chain reaction (qRT-PCR).

Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean.

Within the world's oceans, regionally distinct ecological niches develop due to differences in water temperature, nutrients, food availability, predation and light intensity. This results in differences in the vertical dispersion of planktonic foraminifera on the global scale. Understanding the controls on these modern-day distributions is important when using these organisms for paleoceanographic reconstructions.

Layered double hydroxide-carbon dot composite: high-performance adsorbent for removal of anionic organic dye.

It would be of significance to design a green composite for efficient removal of contaminants. Herein, we fabricated a facile and environmentally friendly composite via direct assembly of surface passivated carbon dots with abundant oxygen-containing functional groups on the surface of the positively charged layered double hydroxide (LDH). The resulting LDH-carbon dot composites were characterized by X-ray diffraction (XRD), Fourier transformed infrared (FTIR) spectroscopy, high resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), and N2 adsorption-desorption technique.

Calligraphy and meditation for stress reduction: an experimental comparison.

Background: Chinese calligraphic handwriting (CCH) has demonstrated a new role in health and therapy. Meanwhile, meditation is an traditional and effective method for coping with stress and staying healthy. This study compared the effectiveness of CCH and meditation as distinctive and parallel stress reduction interventions.

Cognitive-neural effects of brush writing of chinese characters: cortical excitation of theta rhythm.

Chinese calligraphy has been scientifically investigated within the contexts and principles of psychology, cognitive science, and the cognitive neuroscience. On the basis of vast amount of research in the last 30 years, we have developed a cybernetic theory of handwriting and calligraphy to account for the intricate interactions of several psychological dimensions involved in the dynamic act of graphic production. Central to this system of writing are the role of sensory, bio-, cognitive, and neurofeedback mechanisms for the initiation, guidance, and regulation of the writing motions vis-a-vis visual-geometric variations of Chinese characters.