Restoring Colistin Sensitivity in Multidrug-Resistant Pathogenic Using Cinacalcet Hydrochloride.

Restoring colistin's efficacy is crucial in addressing the resistance crisis of colistin. This study utilized a high-throughput screening method to identify 43 compounds from 800 FDA-approved drugs that exhibited significant antibacterial effects when combined with colistin. Among these, cinacalcet hydrochloride (CH) was selected for its potential synergistic effect with colistin against multidrug-resistant (MDR) strains, including -positive strains.

[Research Progress on the Correlation Between Oral Frailty and Dietary Intake in Older Adults].

With the increase in age, the oral function of older adults shows an age-related decline, which limits the types, quantity, and quality of their diet. Limited dietary intake can lead to a lack of basic nutrients needed for maintaining oral health, induce a series of oral diseases, and further aggravate the deterioration of oral functions. Oral frailty is the accumulation of mild oral function decline and is an emerging concept in the field of oral health.

Lens Displacement and Retinal Injury in Blunt Eye Trauma.

We aimed to investigate the incidence and prognosis of retinal injury in patients with lens dislocation caused by blunt eye trauma. We retrospectively analyzed 53 patients who underwent lensectomy and vitrectomy for contusive lens dislocation and had no preoperative retinal injuries. Patients were categorized according to the presence of retinal injury discovered intraoperatively.

Sodium dodecyl sulfate rearranges the conformation of transferrin and attenuates its iron-binding capacity.

Sodium dodecyl sulfate (SDS), an anionic surfactant used in many cleaning and hygiene products, is known for its dermal and respiratory toxicity. However, how this surfactant influences the iron dynamics within the body and the mechanism is unknown. We explored the interaction between SDS and human transferrin (HTF), focusing on the effects on iron-binding capacity and structural changes.

Heterocycle-functional steroidal derivatives: Design, synthesis, bioevaluation and SARs of steroidal pyrazolo[1,5-a]pyrimidines as potential ALK inhibitors.

Two series of heterocyclic steroidal pyrazolo[1,5-a]pyrimidines derived from dehydroepiandrosterone (DHEA) and epiandrosterone (EPIA) were designed and synthesized, and these compounds were screened for their potential antiproliferation activities. The preliminary bioassay indicated that some of target compounds exhibited significantly good antiproliferation activities against human melanoma cell line (A875) and human hepatocellular carcinoma (Huh-7) cell lines compared with 5-fluorouracil (5-FU), and some of which present good antiproliferative activities as potential ALK inhibitors. The detailed analysis of structure-activity relationships (SARs) based on the inhibition activities, kinase assay, and molecular docking demonstrated that the antiproliferation activities of these steroidal pyrazolo[1,5-a]pyrimidine might be affected by the β-hydroxyl group of steroidal scaffold and the N atom of pyridine heterocycle.

Outcomes of astigmatic correction with and without two different cyclotorsion compensation methods in small incision lenticule extraction surgery.

Purpose: To compare the astigmatic correction outcomes of small incision lenticule extraction (SMILE) surgery with or without two different cyclotorsion compensation methods.

Methods: This is a prospective randomized clinical trial. Patients with myopic astigmatism that underwent SMILE surgery were randomly divided into static cyclotorsion compensated group (SCC group), slit-lamp group and control group.

The effect of preoperative mechanical bowel preparation in paediatric bowel surgery on postoperative wound related complications: A meta-analysis.

Mechanical bowel preparation (MBP), a routine nursing procedure before paediatric bowel surgery, is widely should in clinical practice, but its necessity remains controversial. In a systematic review and meta-analysis, we evaluated the effect of preoperative MBP in paediatric bowel surgery on postoperative wound-related complications in order to analyse the clinical application value of MBP in paediatric bowel surgery. As of November 2023, we searched four online databases: the Cochrane Library, Embase, PubMed, and Web of Science.

Effect of high hydrostatic pressure on aroma volatile compounds and aroma precursors of Hami melon juice.

High hydrostatic pressure (HHP) treatment is an effective technique for processing heat-sensitive fruits and causes changes in volatile compounds and their precursors while maintaining quality. We investigated the changes and correlations of volatile compounds, related enzyme activities and precursor amino acids, and fatty acids in Hami melon juice under 350-500 MPa pressure. The application of HHP treatment resulted in a considerable reduction of esters and a substantial increase in aldehydes and alcohols in C6 and C9.

Whole-exome sequencing revealed novel genetic alterations in patients with tetralogy of Fallot.

Background: The most prevalent cyanotic congenital heart disease (CHD) phenotype is tetralogy of Fallot (TOF). Rare genetic variations have been identified as significant risk factors for CHD. Thus, this research sought to identify the pathogenic variations and molecular etiologies of TOF.

Construction and evaluation of a predictive model for compassion fatigue among emergency department nurses: A cross-sectional study.

Background: Compassion fatigue is a syndrome resulting from long-term work-related traumatic event stress exposure of medical staff. The emergency department is considered to be a high-risk, high-intensity and high-stress work environment, with a high prevalence of trauma and violence. Nurses in the emergency department are more prone to compassion fatigue than nurses in other departments.

Canagliflozin Inhibited the Activity of Hemolysin and Reduced the Inflammatory Response Caused by .

Highly virulent () infections can cause Streptococcal toxic shock-like syndrome (STSLS) in pigs and humans, in which an excessive inflammatory response causes severe damage. Hemolysin (SLY) is a major virulence factor of serotype 2 that produces pores in the target cell membrane, leading to cytoplasmic K efflux and activation of the NLRP3 inflammasome, ultimately causing STSLS. The critical aspect of hemolysin in the pathogenesis of type 2 makes it an attractive target for the development of innovative anti-virulence drugs.

[Effect of Pulsating Vacuum Cleaning Sterilizer on the Cleaning Quality of Dental Handpieces].

Objective: To explore the effect of pulsating vacuum cleaning sterilizer on the cleaning quality of dental handpieces.

Methods: A total of 390 newly-purchased high-speed dental handpieces were covered in the study. By the random number table method, the handpieces were divided into three groups that were cleaned by different methods-Group A ( =130), pulsating vacuum cleaning sterilizer, group B ( =130), automatic thermal cleaning and disinfection machine, and group C ( =130), manual cleaning.

Next-generation sequencing technology for the diagnosis of pneumonia in an immunocompetent female: A case report.

Background: pneumonia (PCP) is a serious fungal infection usually seen in patients with human immunodeficiency virus, and it is more frequently found and has a high fatality rate in immunocompromised people. Surprisingly, it rarely occurs in immunocompetent patients. However, the clinical diagnosis of this pathogen is made more difficult by the difficulty of obtaining accurate microbiological evidence with routine tests.

Clinical Features, Antibiotic Susceptibilities, and Outcomes of Endophthalmitis Caused by Streptococcal Infection: Children vs. Adults.

spp. are common causative organisms of endophthalmitis. Analysis of the clinical features, antibiotic susceptibilities, and outcomes of streptococcal endophthalmitis in children and adults may guide future management.

Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf.

To discover bioactive natural products from mangrove sediment-derived microbes, a chemical investigation of the two Beibu Gulf-derived fungi strains, sp. SCSIO 41050 and sp. SCSIO 41411, led to the isolation of 23 natural products.

Novel Steroidal[17,16-]pyrimidines Derived from Epiandrosterone and Androsterone: Synthesis, Characterization and Configuration-Activity Relationships.

Two series of novel steroidal[17,16-]pyrimidines derived from natural epiandrosterone and androsterone were designed and synthesized, and these compounds were screened for their potential anticancer activities. The preliminary bioassay indicated that some of these prepared compounds exhibited significantly good cytotoxic activities against human gastric cancer (SGC-7901), lung cancer (A549), and hepatocellular liver carcinoma (HepG2) cell lines compared with 5-fluorouracil (5-FU), epiandrosterone, and androsterone. Especially the respective pairs from epiandrosterone and androsterone showed significantly different inhibitory activities, and the possible configuration-activity relationships have also been summarized and discussed based on kinase assay and molecular docking, which indicated that the inhibition activities of these steroidal[17,16-]pyrimidines might obviously be affected by the configuration of the hydroxyl group in the part of the steroidal scaffold.

Antiviral Activity of Benzoheterocyclic Compounds from Soil-Derived Streptomyces jiujiangensis NBERC-24992.

Pseudorabies virus (PRV) is a pathogen that causes Aujeszky's disease (AD) in animals, leading to huge economic losses to swine farms. In order to discover anti-PRV compounds, we studied the extracts of the strain NBERC-24992, which showed significant anti-PRV activity. Eight benzoheterocyclic secondary metabolites, including three new compounds (-, virantmycins D-G) and five known compounds (-, virantmycin, A-503451 D, A-503451 D acetylate, A-503451 A, and A-503451 B), were isolated from the broth of NBERC-24992.

Napyradiomycin A4 and Its Relate Compounds, a New Anti-PRV Agent and Their Antibacterial Activities, from WS-68302.

Two new napyradiomycins derivatives, napyradiomycin A4 () and A80915 H (), along with five known ones, were isolated from the ethyl acetate extract of fermentation culture of WS-68302. Their structures were elucidated by extensive spectroscopic analysis, including HR-MS, 1D and 2D NMR, CD spectrum, as well as comparison with literature data. Compound exhibited significant antiviral activity against PRV (Pseudorabies virus) with an IC value of 2.

IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway.

Endothelial aging is a sign of vascular aging that predisposes patients to vascular disease. We explored the effects of IL-17A on endothelial cell aging and determined the potential underlying mechanisms. In human umbilical vein endothelial cells, IL-17A promoted senescence, evidenced as increased positive staining of senescence-associated β-galactosidase, increased proportion of cells arrested at G0/G1 stage, and upregulated p21 and p16 expression.

Interaction, bioaccessibility and stability of bovine serum albumin-gamma-oryzanol complex: Spectroscopic and computational approaches.

The study explored the interaction mechanism between bovine serum albumin (BSA) and gamma-oryzanol (GO) by spectroscopic and computational approaches and the potential to enhance bioaccessibility and chemical stability of GO in the complex with BSA. Fluorescence spectroscopy showed that GO was bound to BSA with static quenching at a single binding site, being consistent with molecular docking results. Thermodynamic analysis and molecular dynamics simulation showed that electrostatic forces dominated interactions between BSA and GO.

Endophthalmitis Caused by : Clinical Characteristics, Outcomes, and Antibiotics Sensitivities.

Purpose: The aim of this study is to report the clinical characteristics, visual outcomes, and antibiotic susceptibilities of patients with endophthalmitis.

Methods: The medical records of patients with culture-proven endophthalmitis treated from June 2013 to December 2019 were reviewed.

Results: This study included 36 eyes of 36 patients.