Exploring a multisource-data framework for assessing ecological environment conditions in the Yellow River Basin, China.

Ecological environment conditions (EEC) assessment plays an important role in watershed management. However, due to insufficient field data, EEC assessment in large-scale watersheds faces challenges. Our study was conducted to develop an effective EEC assessment method framework that was capable of reducing the use of field data.

Evaluating the water quality characteristics and tracing the pollutant sources in the Yellow River Basin, China.

Evaluating water quality characteristics (WQC) and tracing pollutant sources (PS) have gradually attracted worldwide attention. This study was conducted to develop an integrated method framework for evaluating WQC, tracing PS, and improving understanding of their relationship to efficiently managing the water environment. The single-factor index, comprehensive water quality index (CWQI), and hazard quotient and hazard index (HQ and HI) were used to evaluate the characteristics of single pollutant concentration, comprehensive concentration, and human health risk, respectively.

The driving effect of technological innovation on green development: dynamic efficiency spatial variation.

In order to further explore the internal transmission mechanism between technological innovation and green development in manufacturing industry under the background of obvious development characteristics in the new era, this paper constructed an integrated methodology system to evaluate the internal impact mechanism of technological innovation value chain efficiency on green development efficiency based on spatial perspective. First, the Network Slack-based model and Global Malmquist-Luenberger model are constructed to reveal the internal development law of technological innovation and green development of manufacturing industry. Secondly, the spatial Dubin model is employed to analyze the impact of current development characteristics and technological innovation on green development.

Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea.

Background: Obstructive Sleep Apnea (OSA) is a highly prevalent condition that is associated with several comorbidities including cardiovascular disease (CVD). Recent studies have revealed mixed results as to whether standard OSA therapy reverses CVD in adult patients. Thus, many advocate for earlier recognition of OSA induced CVD, as early as childhood, to prompt treatment antecedent to the onset of irreversible CVD.

Energy conservation potential analysis of Chinese manufacturing industry: the case of Jiangsu province.

Improving energy conservation efficiency is one of the prerequisites for China's manufacturing industry to transform and upgrade. Jiangsu province which presents the maximum economic volume in manufacturing and its economic status in eastern China is comparable to Shanghai. Research on the sustainable development capacity of Jiangsu's manufacturing industry gives important guidance for upgrading the manufacturing industry all over China.

Coxsackievirus B3 induces viral myocarditis by upregulating toll-like receptor 4 expression.

In the present study, we investigated the potential pathogenesis of coxsackievirus B3 (CVB3)-induced viral myocarditis and the promising protective effect of silencing RNA (small interfering RNA, siRNA). One hundred and twenty mice were included in the study, and 30 mice were intraperitoneally inoculated with CVB3 to establish an acute viral myocarditis model. The survival rate was observed for the CVB3-infected mouse model (MOD), and myocardial injury was examined by HE (hematoxylin and eosin) staining assay.

Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP-triggered apoptosis via the inhibition of the IRE-α pathway.

Clinically, diabetes mellitus is closely associated with and induces certain cardiovascular diseases. The aim of this study was to investigate endoplasmic reticulum (ER) stress-associated apoptosis of diabetic cardiomyopathy (DCM), and explore the protective mechanism of liraglutide. The DCM model was established with a high-fat diet and streptozotocin (STZ).

Immunocytochemical and immunohistochemical application of monoclonal antibodies against peroxisomal biogenesis factor 14.

PEX14 is an integral membrane protein essential for protein docking onto the peroxisomes and is a bi-functional protein capable of acting as a transcriptional co-repressor and a polypeptide transport modulator. Further studies showed that PEX14 is the sole peroxin that has a unique dual function in peroxisome formation and selective degradation. Its RNA transcripts are ubiquitously expressed; there is, however, no data on the expression profiles of PEX14 at the protein level due to a lack of MAbs suitable for immunohistochemical staining, thus hindering studies on its functions.

[Changes of Foxp3(+); regulatory T cells in patients with acute coronary syndrome].

Aim: To investigate the changes of Foxp3(+); (including CD4(+);Foxp3(+); and CD4(+);CD25(+);Foxp3(+);) regulatory T cells (Tregs) in patients with acute coronary syndrome (ACS).

Methods: Forty-four ACS patients, twenty patients with stable angina (SA) and twenty-four control patients were enrolled. The percentages of the peripheral Tregs, Foxp3 mRNA and plasma level of TGF-β1 were measured by flow cytometry, real-time quantitative PCR and ELISA.

Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome.

Objective: Th1 activation and regulatory T (Treg) cell suppression have been observed in acute coronary syndrome (ACS), including unstable angina (UA) and acute myocardial infarction (AMI). However, the role of Th17 cell or IL-17A remains controversial in ACS patients, and little is known about the role of recently discovered Th17/Th1 cells, a subset of Th17 cells, in coronary artery disease (CAD). The purpose of this study is to investigate functional changes of Th17/Th1, Th17, Th1, Th2 and Treg cells in ACS patients.