Publications by authors named "Manjusha Pal"
Understanding genetic variations associated with familial breast cancer.
World J Surg Oncol
October 2024
Article Synopsis
- - Breast cancer is the most common cancer in women, with genetics accounting for 15-25% of cases, primarily involving mutations in genes like BRCA1 and BRCA2.
- - A comprehensive review of 768 articles identified 20 familial breast cancer-associated genes categorized by their penetrance levels and uncovered 10 genetic disorders related to the disease.
- - The National Comprehensive Cancer Network recommends genetic screening, focusing on high- and moderate-risk gene variations, and highlights the potential of next-generation sequencing (NGS) to uncover rare genetic links to breast cancer.
A 60-year-old man presented with complaints of abdominal pain and melena. Patient had a history of colon cancer 16 years back and had undergone right hemi colectomy for microsatellite instability (MSI) negative, mismatch repair (MMR) stable, T2N0 disease with no mutations on next-generation sequencing (NGS). Investigations revealed a second primary in stomach (intestinal type of adenocarcinoma) with no recurrent lesions in colon or distant metastasis.
View Article and Find Full Text PDFBackground: PARP inhibitors (PARPi) have a well-established role in platinum-sensitive ovarian cancer (PSOC), in BRCA mutant (BRCAm), and homologous recombination deficiency (HRD) population. However, their role in wild type and homologous recombination proficient population is still not clear.
Methods: A meta-analysis of hazard ratios (HR) of randomized control trials (RCTs) was conducted to study the role of PARPi.