Discovery of three-dimensional bicyclo[3.3.1]nonanols as novel heat shock protein 90 inhibitors.

We developed an efficient synthetic method for constructing bicyclo[3.3.1]nonane, an sp-carbon-rich three-dimensional scaffold consisting of two fused six-membered rings.

Click Synthesis of Triazole Polymers Based on Lignin-Derived Metabolic Intermediate and Their Strong Adhesive Properties to Cu Plate.

2-Pyrone-4,6-dicarboxylic acid (PDC) is a chemically stable metabolic intermediate of lignin that can be produced on a large scale by transforming bacteria. Novel biomass-based polymers based on PDC were synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and fully characterized by nuclear magnetic resonance, infrared spectroscopies, thermal analysis, and tensile lap shear strength measurements. The onset decomposition temperatures of these PDC-based polymers were all above 200 °C.

Mental state and emotion detection from musically stimulated EEG.

This literature survey attempts to clarify different approaches considered to study the impact of the musical stimulus on the human brain using EEG Modality. Glancing at the field through various aspects of such studies specifically an experimental protocol, the EEG machine, number of channels investigated, feature extracted, categories of emotions, the brain area, the brainwaves, statistical tests, machine learning algorithms used for classification and validation of the developed model. This article comments on how these different approaches have particular weaknesses and strengths.

Probing influence of methodological variation on active loading of acetazolamide into nanoliposomes: biophysical, in vitro, ex vivo, in vivo and rheological investigation.

In the present work comparative evaluation of acetate and pH gradient techniques for effective drug loading in liposomes has been investigated. The acetazolamide (ACZ) loaded liposomes prepared by two methods were analyzed by vesicle size analysis, zeta potential, percent encapsulation efficiency, in vitro drug release studies and intraocular pressure lowering activity. ICH guidelines were followed for determining stability of the prepared liposomes.