Publications by authors named "Manjunath P R"
Article Synopsis
- Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often beginning in adolescence, which was the focus of this study that compared serum irisin levels in women with PCOS to healthy controls.
- The research involved 33 women with PCOS and 32 healthy counterparts, measuring clinical data, body composition through bioelectrical impedance analysis, and serum irisin via ELISA.
- Results showed that women with PCOS had significantly higher serum irisin levels and various health markers related to metabolic issues, with positive correlations between irisin and factors like blood pressure, cholesterol, and testosterone.
Article Synopsis
- The study examined the characteristics of adrenal incidentalomas (AIs) in 62 patients over seven years in South India, focusing on their clinical profiles and surgical outcomes.
- Most patients were middle-aged or older, with pain as the primary reason for imaging; nearly half of the evaluated tumors were functional.
- Histopathological results indicated that adenomas were the most common type found, with a notable number of functional tumors being ≥4 cm, which may indicate a higher malignancy risk.
Objectives: With the menopausal transition, there is a decline in estrogen concentration with potential health consequences affecting the quality of life. The loss of muscle mass, strength, and function, known as sarcopenia is common in postmenopausal women. The primary objective of this study is to assess the quality of life in postmenopausal women and its association with sarcopenia.
View Article and Find Full Text PDFBackground: Subclinical thyrotoxicosis (SCH) is characterized by normal serum thyroid hormone levels and low thyrotropin levels. The impact of this condition on the skeletal system may vary depending on its cause, yet the relationship is not fully comprehended in premenopausal women. Studies are scarce about its effects on bone health in our population.
View Article and Find Full Text PDFPrevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus.
J Family Med Prim Care
September 2023
Introduction: Cardiac autonomic neuropathy (CAN) is one of the microvascular complications of diabetes mellitus, which is due to the involvement of autonomic nerve fibers innervating the heart and blood vessels. CAN was found to have a greater degree of morbidity and mortality than their non-CAN counterparts as it is underdiagnosed. Hence, this study aims to determine the prevalence and severity of CAN in type 2 diabetics in the South Indian setting.
View Article and Find Full Text PDFIntroduction: Pheochromocytoma is a catecholamine-secreting tumor arising from adrenomedullary chromaffin cells that has a varied clinical presentation. Identification of this tumor, which has episodic symptoms, is a diagnostic challenge for clinicians. Diagnosis at an appropriate time is important because it is associated with significant morbidity and mortality.
View Article and Find Full Text PDFContext: Medullary thyroid carcinoma (MTC), being an aggressive disease, requires meticulous follow-up and multidisciplinary management. The clinical presentation, management, outcome of MTC varies among different populations.
Aims: An audit was conducted to evaluate the demography, clinical presentation, management, and outcome of MTC in a tertiary care center in South India.
Context: Insulin autoantibody syndrome (IAAS) is considered to be a rare cause of hyperinsulinaemic hypoglycaemia. Lack of familiarity with the varied clinical manifestations leads to underdiagnosis. Localization techniques aimed at insulin-secreting neoplasms and nesidioblastosis, which are expensive often are ordered when the correct diagnosis is not made.
View Article and Find Full Text PDF"Riding High on Low Fuel" - Our Experience with Endogenous Hyperinsulinemic Hypoglycemia.
Indian J Endocrinol Metab
January 2017
Introduction: Endogenous hyperinsulinemic hypoglycemia (EHH) is a condition in which the insulin levels are inappropriately high in the presence of low plasma glucose.
Materials And Methods: We did a retrospective analysis of case records of those patients admitted and evaluated for EHH from June 2004 to June 2016 in our center, excluding those that were diagnosed with reactive hypoglycemia. We collected data regarding demographics, clinical presentation, laboratory results, localization techniques, and treatment administered.