Publications by authors named "Manjul Agarwal"

To treat alopecia, there are many surgical and nonsurgical treatments available nowadays. In the surgical one, the Biofibre® hair implantation system represents an important innovation with artificial hair with special physical, chemical, and mechanical features and the new Biofibre® Automatic device. Implant on 1,518 patients has been reported in this study where the Biofibre® hair implant technique is performed on men and women with varying degrees of baldness and for the treatment of various causes of alopecia such as androgenetic alopecia, burns, and scars.

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Article Synopsis
  • Research on human bone marrow endothelial cells (HBMEC) showed that aldosterone exposure for 8 hours led to the upregulation of 6 genes and downregulation of 4 genes related to blood clotting (hemostasis).
  • The study detected the endothelial protein C receptor (EPCR) on cell membranes and found that the mineralocorticoid receptor (MCR) was present in the cell nucleus and cytoplasm.
  • Aldosterone treatment increased clotting time significantly when HBMEC were exposed to activated protein C, and MCR blockers reduced coagulation time, indicating complex interactions between mineralocorticoid hormones and blood clotting mechanisms.
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Sodium-water balance is causally linked to the functional expression of a number of important ocular tissues, viz. corneal deturgescence, aqueous humor secretion by the iris, hydration of the lens, retinal photoreception, and choriocapillary angiogenesis. The regulation of sodium absorption in the eye is generally believed to be under the control of Na(+),K(+)-activated adenosine triphosphatase, although evidence for this view is at best circumstantial.

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We investigated the possibility of utilizing alga cells instead of mammalian cells for the screening of anticancer drugs. The alga cells grow in synthetic media whereas the mammalian cells require complex and more expensive media along with heavy investment and manpower. To assess the validity of this new approach, analysis of growth inhibition by antitumor agents was carried out jointly on a wall-less (cw15) mutant of Chlamydomonas reinhardtii, that obviates the problem of drug uptake, and the murine leukemic cell line L1210, commonly used for anticancer drug screening.

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