Publications by authors named "Manjot Singh"

Adult spinal deformity (ASD) commonly affects older adults, with up to 68% prevalence in those over 60, and is often complicated by osteoporosis, which reduces bone mineral density (BMD) and increases surgical risks. Osteoporotic patients undergoing ASD surgery face higher risks of complications like hardware failure, pseudoarthrosis, and proximal junctional kyphosis (PJK). Medical management with antiresorptive medications (e.

View Article and Find Full Text PDF

: Degenerative cervical myelopathy is a progressive neurological disorder that is commonly encountered in clinical practice and its incidence is expected to increase alongside the aging population. Given the importance of early and accurate diagnosis in this patient population, this narrative review aims to provide a repository of up-to-date information regarding pertinent patient history, physical exam findings, and potential alternate diagnoses. : The PubMed database was queried for publications from 1 January 2019 to 19 March 2024.

View Article and Find Full Text PDF

Background And Context: The optimal timing at which patients should undergo Anterior Cervical Discectomy and Fusion (ACDF) surgery to achieve the best outcomes has not been determined. Given that patients may experience delays in care and that insurance companies often require a minimum of six weeks of conservative treatment before surgery, it is essential to determine the impact of symptom duration on outcomes following ACDF.

Purpose: To evaluate the impact of symptom duration on outcomes following ACDF surgery.

View Article and Find Full Text PDF
Article Synopsis
  • * Prone chest compressions were performed immediately during the surgery, allowing the patient to survive without any postoperative issues.
  • * The incident highlights the challenges of treating cardiac arrest due to a venous air embolism (VAE) in spinal surgery and suggests that prone chest compressions may be more effective than waiting to switch to supine positioning for CPR.
View Article and Find Full Text PDF

Introduction: Postoperative delirium (POD) is a feared complication following major surgery in elderly patients. Further investigation of the risk factors and consequences of POD following total joint arthroplasty is warranted.

Methods: Patients who underwent total knee arthroplasty (TKA) or total hip arthroplasty (THA) were identified using PearlDiver.

View Article and Find Full Text PDF

Background Context: As surgical indications for cervical disc arthroplasty (CDA) continue to expand, a growing patient population is now becoming indicated for this procedure. Little is known about whether CDA is safe in the overweight and obese populations, and how this procedure compares to anterior cervical discectomy and fusion (ACDF) in this particular demographic.

Purpose: To evaluate the outcomes of CDA across varying levels of body mass indices and to compare these to ACDF.

View Article and Find Full Text PDF

Background: Total knee arthroplasty (TKA) is frequently performed to reduce pain and improve quality of life. Patient satisfaction following TKA is commonly reported at 80%. However, given recent advancements in perioperative management, implants, and operative techniques, new assessments on patient satisfaction are warranted.

View Article and Find Full Text PDF

Background: Patients with atrial fibrillation (AF) often require lifetime anticoagulation using drugs such as Warfarin and Direct-acting Oral Anticoagulants (DOAC). It is important to assess the impact that prior anticoagulant use has on the post-operative complications in patients with AF undergoing TKA.

Methods: This is a retrospective analysis of the PearlDiver database querying all patients who underwent an inpatient TKA.

View Article and Find Full Text PDF

Vertebral fractures are a common cause of back pain and pain-related functional impairments in elderly patients. Despite their widespread occurrence, vertebral fractures frequently remain underdiagnosed, often leading to suboptimal management and poor clinical outcomes. This review specifically examines the role of physical therapy (PT) in managing vertebral fractures, describing current literature and evidence-based guidelines from the American Physical Therapy Association and the American Academy of Orthopaedic Surgeons.

View Article and Find Full Text PDF

Background Context: Postoperative pain management in spine surgery remains a challenge. Liposomal bupivacaine (LB) has emerged as an alternative or adjunct to opioid-based analgesia. However, existing studies evaluating LB efficacy in spine surgery yield conflicting results and a meta-analysis compiling the literature is lacking.

View Article and Find Full Text PDF

Purpose: Understanding the mechanism and extent of preoperative deformity in revision procedures may provide data to prevent future failures in lumbar spinal fusion patients.

Methods: ASD patients without prior spine surgery (PRIMARY) and with prior short (SHORT) and long (LONG) fusions were included. SHORT patients were stratified into modes of failure: implant, junctional, malalignment, and neurologic.

View Article and Find Full Text PDF
Article Synopsis
  • Atrial fibrillation patients often require anticoagulants like warfarin or DOACs to prevent complications, and this study investigates how these medications affect outcomes after outpatient total knee arthroplasty (TKA).
  • A claims database was analyzed, comparing patients who took warfarin (4,396) or DOACs (5,383) with matched controls, both groups averaging around 70 years old.
  • Results revealed that patients on warfarin had more pulmonary embolisms but fewer TKA revisions, while those on DOACs had higher pneumonia and myocardial infarction rates, but fewer surgical complications than matched controls.
View Article and Find Full Text PDF

Two-dimensional transition metal dichalcogenides, particularly MoS, are interesting materials for many applications in aerospace research, radiation therapy and bioscience more in general. Since in many of these applications MoS-based nanomaterials can be placed in an aqueous environment while exposed to ionizing radiation, both experimental and theoretical studies of their behaviour under these conditions is particularly interesting. Here, we study the effects of tiny imparted doses of 511 keV photons to MoS nanoflakes in water solution.

View Article and Find Full Text PDF
Article Synopsis
  • This study is a retrospective cohort analysis that examines how inadequate correction of lumbar lordosis at L4-S1 during TLIF affects the development of adjacent segment disease and the need for revision surgeries.
  • It included 168 patients, primarily around 61 years old, who underwent 1-3 level TLIF, and the findings indicated that inadequate lordosis restoration led to significantly higher rates of adjacent segment disease (33.3% vs. 6.7%) and revision surgeries (25.9% vs. 5.7%).
  • The results highlight the importance of achieving proper alignment to reduce complications and improve patient outcomes after spinal fusion surgery.
View Article and Find Full Text PDF
Article Synopsis
  • Surgical management of adolescent idiopathic scoliosis (AIS) and Scheuermann's kyphosis (SK) can lead to complications like longer hospital stays and unplanned surgeries, but there hasn't been a comprehensive meta-analysis on this topic.
  • The meta-analysis reviewed seven studies involving 4,866 patients and found that SK patients had significantly higher rates of complications, surgical-site infections, readmissions, and reoperations compared to AIS patients, even though their SRS-22 satisfaction scores were similar post-surgery.
  • The findings suggest that while SK patients experience more complications from surgery, the surgical treatment still provides similar quality of life outcomes as seen in AIS patients.
View Article and Find Full Text PDF

Background: Postoperative delirium (POD) is frequently reported in the elderly after major surgery. Several risk factors have been identified, including age, surgical complexity, and comorbidities.

Methods: Posterior lumbar fusion patients were identified using PearlDiver and filtered into two cohorts based on the presence or absence of POD within 7 days of surgery.

View Article and Find Full Text PDF

Background: Several assessment tools have been developed to estimate a patient's likelihood risk of falling. None of these measures estimate the contributions of the visual, vestibular, and somatosensory systems to fall risk, especially in patients with degenerative lumbar spine disease.

Methods: Degenerative lumbar spine patients with radiculopathy (LD) and healthy subjects who were 35-70 years old without spine complaints were recruited.

View Article and Find Full Text PDF
Article Synopsis
  • The study is a retrospective cohort analysis comparing outcomes of one-level transforaminal lumbar interbody fusion (TLIF) at L4-L5 versus L5-S1 in patients with degenerative lumbar conditions.
  • Researchers evaluated patient demographics, surgical details, changes in spinopelvic alignment, patient-reported outcomes, and two-year postoperative complications, finding that L5-S1 TLIF achieved better alignment correction but at the cost of higher complication rates.
  • Specifically, patients with L5-S1 TLIF had significantly higher occurrences of pseudoarthrosis and subsequent surgeries related to it, while patient-reported outcomes remained similar between both groups.
View Article and Find Full Text PDF

Study Design: Retrospective cohort study.

Objective: Compare outcomes in patients undergoing one-level or two-level anterior lumbar interbody fusion (ALIF) at L4-S1.

Background: Although ALIF may deliver restoration of lumbar lordosis and improvement in clinical outcomes, it also carries risk of complications including major vascular injury.

View Article and Find Full Text PDF

Spinal alignment analysis play an important role in evaluating patients and planning surgical corrections for adult spinal deformity. The history of these parameters is relatively short with the first parameter, the Cobb angle, introduced in 1948 as part of an effort to improve scoliosis evaluation. New developments in the field were limited for nearly 30 years before better imaging technology encouraged new theories and later data about spinal alignment and the relationship between the spine and pelvis.

View Article and Find Full Text PDF

Study Design: Retrospective analysis of prospectively collected data.

Objective: Evaluate the impact of prior cervical constructs on upper instrumented vertebrae (UIV) selection and postoperative outcomes among patients undergoing thoracolumbar deformity correction.

Background: Surgical planning for adult spinal deformity (ASD) patients involves consideration of spinal alignment and existing fusion constructs.

View Article and Find Full Text PDF

Background: Prior reviews investigating the impact of pregnancy on adolescent idiopathic scoliosis (AIS) have reached different conclusions and a meta-analysis of curve progression among pregnant females with AIS and its effects on clinical outcomes has not previously been performed.

Methods: A comprehensive search of major bibliographic databases (PubMed, Embase, and Scopus) was conducted for articles pertaining to spinal curve progression during pregnancy among patients with AIS. Patient demographics, scoliotic curve outcomes, and patient-reported quality of life measures were extracted.

View Article and Find Full Text PDF
Article Synopsis
  • Vertebral fractures, particularly cervical and thoracic, lead to long-term back pain, decreased quality of life, and higher morbidity and mortality, highlighting a need for better epidemiological data.
  • This study analyzes the trends in incidence, patient demographics, and injury mechanisms of these fractures in the US from 2003 to 2021 using data from the NEISS-AIP database.
  • Findings show a significant rise in the incidence of cervical and thoracic fractures across all age groups, especially in those aged 80 and older, with most injuries occurring at home.
View Article and Find Full Text PDF