Harnessing rat derived model cells to assess the toxicity of TiO nanoparticles.

Until now, a few studies have been conducted on the destructive effects of TiO NPs in living organisms, and studies on the toxicity of TiO NPs are still in the beginning phases. Because of the widespread use of TiO NPs in all areas of human life, it is essential to study their profound and fundamental toxic effects on each organ and body cell. Herein, we evaluate the effect of exposure to TiO NPs on in vitro models derived from the rat bone marrow and adipose tissues.

Cellular senescence in cancers: relationship between bone marrow cancer and cellular senescence.

Introduction: There are many factors and conditions that lead to cellular senescence. Replicative senescence and Hayflick phenomenon are the most important causes of cellular senescence. Senescent cells also lead to wound healing conditions resulting from injury and toxic conditions.

Zinc oxide nanoparticles promote the aging process in a size-dependent manner.

Zinc oxide (ZnO) nanoparticles (NPs) are generally utilized in cosmetic goods, sheds, biosensors, and delivery of drug. As in vitro ideal systems, mesenchymal stem cells (MSCs) are used to test acute toxicity. In the present study, size-dependent cytotoxicity effects of ZnO NPs on MSCs were assessed.