Publications by authors named "Manita Mehmi"
There are no current stratified medicine options for STK11-deficient NSCLC. STK11 loss mediates mTORC activation, GLUT1 up-regulation and increased glycolysis. This metabolic reprogramming might represent a therapeutic vulnerability targetable with mTORC1/2 inhibition.
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Article Synopsis
- * The National Lung Matrix Trial is the largest umbrella trial in NSCLC, utilizing next-generation sequencing to match patients with suitable targeted therapies based on their tumour's genetic profile, involving 19 drug-biomarker cohorts.
- * Though 5,467 patients were screened, only 2,007 qualified for the trial, with 302 receiving genotype-matched therapies; however, only a few drug-biomarker combinations showed meaningful clinical benefits, primarily in those with minimal tobacco exposure.
Evaluation of disinfecting procedures for aseptic transfer in hospital pharmacy departments.
PDA J Pharm Sci Technol
August 2009
Current practice in National Health Service (NHS) hospitals employs 70% Industrial Methylated Spirit spray for surface disinfection of components required in Grade A pharmaceutical environments. This study seeks to investigate other agents and procedures that may provide more effective sanitisation. Several methods are available to test the efficacy of disinfectants against vegetative organisms.
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