Publications by authors named "Manishkumar A Chaube"
Article Synopsis
- Cellulose and chitin are key structural polysaccharides used in various applications due to their crystallinity, and chemical modifications help alter their properties but create complex mixtures.
- The study focused on how deoxyfluorination affects the solubility and aggregation of cellulose and chitin oligomers, finding that it improved the solubility of cellulose but had minimal impact on chitin.
- The research underscores the importance of specific hydroxyl groups in crystallization and offers insights for designing cellulose- and chitin-based materials that resist enzymatic degradation.
Oligosaccharide fragments of fungal cell wall glycans are important molecular probes for studying both the biology of fungi and fungal infections of humans, animals, and plants. The fungal cell wall contains large amounts of various polysaccharides that are ligands for pattern recognition receptors (PRRs), eliciting an immune response upon recognition. Towards the establishment of a glycan array platform for the identification of new ligands of plant PRRs, tri-, penta-, and heptasaccharide fragments of different cell wall polysaccharides were prepared.
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- The arrangement, length, and types of substitutions in polysaccharides determine their physical and biological characteristics, making sequence-controlled polysaccharides essential for understanding structure-properties relationships.
- Polymerization methods and enzymatic techniques have been refined to produce polysaccharides with specific substitution patterns and consistent molecular weights.
- This review examines advancements in synthesizing well-defined polysaccharides while highlighting the different synthetic methods and their limitations for each polysaccharide class.
Chitin, a polymer composed of β(1-4)-linked N-acetyl-glucosamine monomers, and its partially deacetylated analogue chitosan, are abundant biopolymers with outstanding mechanical as well as elastic properties. Their degradation products, chitooligosaccharides (COS), can trigger the innate immune response in humans and plants. Both material and biological properties are dependent on polymer length, acetylation, as well as the pH.
View Article and Find Full Text PDFTotal synthesis of three important trehalose containing tetrasaccharides isolated from Mycobacterium smegmatis is reported for the first time, using regioselective opening of benzylidene acetals and stereoselective glycosylations as key steps. The 1,2-cis stereoselectivity in the glycosylation reactions was achieved using anchimeric assistance from a remote participating group, steric effects and solvent participation. The synthetic strategy can also be utilized for the assembly of structurally related oligosaccharides from M.
View Article and Find Full Text PDFThe first total synthesis of the branched oligosaccharide OSE-1 of Mycobacterium gordonae (strain 990) is reported. An intramolecular aglycon delivery approach was used for constructing the desymmetrized 1,1'-α,α-linked trehalose moiety. A [3+2] glycosylation of the trisaccharide donor and trehalose acceptor furnished the right hand side pentasaccharide.
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