Comparative Evaluation of Serum Copeptin in Obesity with Non Alcoholic Fatty Liver Disease.

Introduction: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of liver disease in India. NAFLD is regarded as the metabolic syndrome's hepatic component. AVP has a significant impact on glucose and lipid metabolism by stimulating hepatic glycogenolysis, gluconeogenesis, and fat production by modulating insulin and glucagon release from the pancreatic Langerhans' islets.

Combined saposin deficiency: A rare occurrence.

Combined saposin deficiency (OMIM #611721), an exceedingly rare lysosomal storage disorder, is caused by a mutation in the gene . This gene encodes a protein, prosaposin, that cleaves into four constituent proteins, each of which has a role as a cofactor for the enzymes whose deficiency results in Krabbe disease, metachromatic leukodystrophy, Gaucher disease, and Farber disease, respectively. Intact prosaposin itself is essential for neuronal survival.

Plants and their Bioactive Compounds as a Possible Treatment for Traumatic Brain Injury-Induced Multi-Organ Dysfunction Syndrome.

Background & Objective: Traumatic brain injury is an outcome of the physical or mechanical impact of external forces on the brain. Thus, the silent epidemic has complex pathophysiology affecting the brain along with extracranial or systemic complications in more than one organ system, including the heart, lungs, liver, kidney, gastrointestinal and endocrine system. which is referred to as Multi-Organ Dysfunction Syndrome.

Doppler hemodynamic liver index and hepatic elastic modulus: Advanced ultrasonographic techniques for non-invasive prediction of esophageal varices in cirrhosis.

Purpose: Currently esophagoscopy is the gold standard for assessment of esophageal varices in cirrhosis. Predicting the presence of esophageal varices, varices needing treatment (VNT) and variceal grade by advanced ultrasonographic techniques using a combination of Doppler hemodynamic liver index (HDLI) (quantifying portal hypertension) and hepatic elastic modulus (quantifying hepatic fibrosis) would be a cost-effective and non-invasive alternative to routine endoscopy.

Methods: Our cross-sectional study consisted of cirrhotic patients diagnosed using clinical features and laboratory parameters.

Phytohormone Priming of Tomato Plants Evoke Differential Behavior in During Infection, With Salicylate Priming Imparting Greater Tolerance Than Jasmonate.

In the field of phytohormone defense, the general perception is that salicylate (SA)-mediated defense is induced against biotrophic pathogens while jasmonate (JA)-mediated defense functions against necrotrophic pathogens. Our goals were to observe the behavior of the necrotrophic pathogen in the vicinity, on the surface, and within the host tissue after priming the host with SA or JA, and to see if priming with these phytohormones would affect the host defense differently upon infection. It was observed for the first time, that could not only distinguish between JA versus SA-primed tomato plants from a distance, but surprisingly avoided SA-primed plants more than JA-primed plants.

Use of steroids in COVID-19 patients: A meta-analysis.

Background: Emerging reports have shown the benefits of steroids in hospitalized COVID-19 patients as life-saving drugs. However, the use of steroids in COVID-19 patients is confusing among many physicians.

Aim: The aim of the current study was to find out the exact association of steroids in the deaths of COVID-19 patients.

Gamma irradiations induced morphological and biochemical variations in in vitro regenerated ginger ( rosc.)- an invaluable medicinal spice.

Purpose: To evaluate the effect of gamma irradiations on morphological and biochemical variations of in vitro shoots, regenerated plants and rhizomes of ginger ( Rosc.) var. Himgiri.

Molecular Mechanism of Arsenic-Induced Neurotoxicity including Neuronal Dysfunctions.

Arsenic is a key environmental toxicant having significant impacts on human health. Millions of people in developing countries such as Bangladesh, Mexico, Taiwan, and India are affected by arsenic contamination through groundwater. Environmental contamination of arsenic leads to leads to various types of cancers, coronary and neurological ailments in human.

Reciprocal relation between reporter gene transcription and translation efficiency in fission yeast.

The fission yeast, Schizosaccharomyces pombe, is an excellent model for basic research but is not useful for commercial scale protein expression due to lack of strong expression vectors. Earlier, we showed that the lsd90 promoter elicited significantly greater GFP expression level than the adh1 and nmt1 promoters, albeit in different vector backbones. Here, we have systematically investigated the contribution of selectable markers, LEU2 and URA3m to GFP expression: while LEU2 elicited very low expression, the URA3m gene, with truncated promoter, elicited much greater GFP expression level with all promoters.

Commercial application of cellulose nano-composites - A review.

Cellulose is the biosynthetic product from plants, animals and bacteria. Cellulose is the most abundant polymer having long linear chain like structure composed of (1,4) linked β-D glucopyranosyl units assembled into hierarchical structures of microfibrils with excellent strength and stiffness. And 'nanocellulose' refers to the cellulosic materials with defined nano-scale structural dimensions.

Oxidative Stress: Major Threat in Traumatic Brain Injury.

Background & Objective: Traumatic Brain Injury (TBI) is one of the major causes of mortality and morbidity worldwide. It represents mild, moderate and severe effects of physical assault to brain which may cause sequential, primary or secondary ramifications. Primary injury can be due to the first physical hit, blow or jolt to one of the brain compartments.

An amperometric HO biosensor based on hemoglobin nanoparticles immobilized on to a gold electrode.

The nanoparticles (NPs) of hemoglobin (Hb) were prepared by desolvation method and characterized by transmission electron microscopy (TEM), UV spectroscopy and Fourier-transform IR (FTIR) spectroscopy. An amperometric HO biosensor was constructed by immobilizing HbNPs covalently on to a polycrystalline Au electrode (AuE). HbNPs/AuE were characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectra (EIS) before and after immobilization of HbNPs.

Autonomic status and pain profile in patients of chronic low back pain and following electro acupuncture therapy: a randomized control trial.

Pain is a syndrome characterized by several neurophysiological changes including that of the autonomic nervous system. Chronic low back pain (LBP) is a major health problem and is a frequent reason for using unconventional therapies especially acupuncture. This study was conducted to evaluate the autonomic status and pain profile in chronic LBP patients and to observe the effect of electro acupuncture therapy.

Load of heavy metals in the airborne dust particulates of an urban city of central India.

The geographical and temporal distribution patterns of airborne dust particulates have been studied in different representative areas of Raipur City. Dust fall samples from different sites were collected and some selected toxic metals namely Cr, Mn, Fe, Ni, Cu, Zn, Sb and Pb in them were determined by AAS. Total annual flux of 11.

In vitro regeneration of Acacia catechu Willd. from callus and mature nodal explants--an improved method.

Callus was derived from cultured cotyledons on MS medium supplemented with 2,4-D (0.25 mg/l) and NAA (0.25 mg/l).