Establishment of patient-derived xenografts of retinoblastoma and choroidal melanoma on the avian chorioallantoic membrane.

Purpose: To develop a viable in vivo chorioallantoic membrane (CAM) model to study the growth and invasion of patient-derived retinoblastoma (RB) and choroidal melanoma (CM) xenografts (PDXs). The study utilizes primary tumor samples instead of cancer cell lines, which provides a more authentic representation of tumors due to conserved morphology and heterogeneity.

Methods: Fertilized chicken eggs were procured, windowed, and their CAM layers were dropped.

Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations.

The high magnitude zoonotic event has caused by Severe Acute Respitarory Syndrome CoronaVirus-2 (SARS-CoV-2) is Coronavirus Disease-2019 (COVID-19) epidemics. This disease has high rate of spreading than mortality in humans. The human receptor, Angiotensin-Converting Enzyme 2 (ACE2), is the leading target site for viral Spike-protein (S-protein) that function as binding ligands and are responsible for their entry in humans.

Contemporary nanocellulose-composites: A new paradigm for sensing applications.

Nanocellulose (NC) is the biological polymeric nanomaterial booming in the international market. The burgeoning demand for cellulose materials and advancements in nanotechnology have intensified the researches on the development of cellulose-based nanomaterials. Substantial research on nanocellulose-based composites in energy, electronics, biomedical, health, and the environment has been carried out in the last few decades.

Hematopoietic Stem Cell Factors: Their Functional Role in Self-Renewal and Clinical Aspects.

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and differentiation. These properties of HSCs are maintained through hematopoiesis. This process gives rise to two subpopulations, long-term and short-term HSCs, which have become a popular convention for treating various hematological disorders.